Studies on 6-[(dimethylamino)methylenelaminouracil:: a facile one-pot synthesis of novel pyrimido[4,5-d]pyrimidine derivatives

被引：57

作者：

Prajapati, D ^{[1
]}

Thakur, AJ

机构：

[1] Reg Res Lab, Dept Med Chem, Jorhat 785006, Assam, India

[2] Cent Univ, Dept Chem Sci, Tezpur 784028, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

关键词：

amidines; pyrimido[4,5-d]pyrimidines; aryl isothiocyanates; aryl isocyanates;

D O I：

10.1016/j.tetlet.2005.01.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of 6-[(dimethylamino)methylene]aminouracil 1, with various heterocumulenes such as aryl isocyanates and isothiocyanates give rise to novel pyrimido[4,5-d]pyrimidines in excellent yields, after elimination of dimethylamine from the (1:1) cycloadducts and tautomerisation. This procedure provides a convenient method for direct synthesis of pyrimido[4,5-d]pyrimidine derivatives under thermal conditions. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1433 / 1436

页数：4

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