Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies

被引：5

作者：

Zizkova, Martina ^{[1
]}

Sucha, Rita ^{[1
]}

Tyleckova, Jirina ^{[1
]}

Jarkovska, Karla ^{[1
]}

Mairychova, Katerina ^{[1
]}

Kotrcova, Eva ^{[1
]}

Marsala, Martin ^{[2
]}

Gadher, Suresh Jivan ^{[3
]}

Kovarova, Hana ^{[1
]}

机构：

[1] AS CR, Lab Appl Proteome Analyses, Inst Anim Physiol & Genet, Vvi, Libechov, Czech Republic

[2] Univ Calif San Diego, Dept Anesthesiol, Neuroregenerat Lab, La Jolla, CA 92093 USA

[3] Thermo Fisher Sci Life Sci Solut, Frederick, MD USA

来源：

EXPERT REVIEW OF PROTEOMICS | 2015年 / 12卷 / 01期

关键词：

cell therapy; immunomodulation; neural stem cell differentiation; neural subpopulation; neurodegenerative disease; population-specific protein-expression signature; quantitative mass spectrometry; selected reaction monitoring; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; PROGENITOR CELLS; NEURONAL DIFFERENTIATION; MEMBRANE PROTEOMICS; IN-VIVO; DYSFUNCTION; OLIGODENDROCYTE; EXPRESSION; PROTEINS;

D O I：

10.1586/14789450.2015.977381

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neural populations is a key challenge. Intracellular proteins may be utilized as a readout for follow-up transplantation and cell surface proteins may facilitate isolation of the cell subpopulations, while secreted proteins could help unravel intercellular communication and immunomodulation. This review summarizes the potential of proteomics in revealing molecular mechanisms underlying neural differentiation of stem cells and presents novel candidate proteins of neural subpopulations, where understanding of their functionality may accelerate transition to cell replacement therapies.

引用

页码：83 / 95

页数：13

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