H19 lncRNA: Roles in tumorigenesis

被引：205
作者：
Ghafouri-Fard, Soudeh [1 ]
Esmaeili, Mohammadhosein [2 ]
Taheri, Mohammad [3 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
[2] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 123卷
关键词：
H19; lncRNA; Cancer; Biomarker; NONCODING RNA H19; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES TUMOR-GROWTH; BREAST-CANCER CELLS; POOR-PROGNOSIS; COLORECTAL-CANCER; UP-REGULATION; DIAGNOSTIC BIOMARKER; DOWN-REGULATION; BLADDER-CANCER;
D O I：
10.1016/j.biopha.2019.109774
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
H19 is a long non-coding RNA [lncRNA] which was firstly described as an oncofetal transcript. The imprinted gene is normally expressed from the maternal allele. However, this pattern of imprinting is dysregulated in several cancers leading to aberrant up-regulation of H19 in malignant tissues. Several studies have utilized this aberrant expression pattern to find specific biomarkers for detection of cancer in tumoral tissues or peripheral blood. Moreover, single nucleotide polymorphisms within H19 have been associated with risk of oral squamous cell carcinoma, hepatocellular carcinoma, breast cancer, bladder cancer, gastric cancer and colorectal cancer. Taken together, H19 is regarded as a biomarker for cancer and a putative therapeutic target in these human disorders.
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页数：10
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