Advances in the Applications of Mucin 1 in Cancer Therapy

被引：1

作者：

Yang, Ben ^{[1
]}

Li, Hanyue ^{[1
]}

Wang, Fei ^{[1
]}

Zuo, Changjun ^{[1
]}

Qi, Yicheng ^{[1
]}

Song, Tiantian ^{[1
]}

Sun, Sipeng ^{[1
]}

Kou, Rongguan ^{[1
]}

Wang, Anping ^{[1
]}

Wang, Hui ^{[1
]}

Shi, Mengqi ^{[1
]}

Yu, Wenjing ^{[1
]}

Wang, Yubing ^{[1
]}

Gao, Zhiqin ^{[1
]}

机构：

[1] Weifang Med Univ, Shandong Univ Key Lab Biopharmaceut, Sch Life Sci & Technol, Weifang 261053, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2022年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mucin; 1; Cancer; Target; Glycosylation; Anti-Tumor; Copyright; American; TARGETED DRUG-DELIVERY; MONOCLONAL-ANTIBODY; ANTITUMOR IMMUNITY; T-CELLS; BREAST; EXPRESSION; VACCINE; NANOPARTICLES; METASTASIS; IMMUNOTHERAPY;

D O I：

10.1166/jbn.2023.3493

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation. Mucin 1 is weakly O-glycosylated in tumor cells, the core site is exposed, and it is widely distributed on the surface of tumor cells, making it an important tumor marker. Mucin 1 has a wide range of applications in tumor diagnosis, tumor drug targeted delivery, and immunodeficiency therapy. Animal studies and clinical studies suggest that mucin 1 can be used as a target in tumor-targeted therapy. This review covers our current summary of the structure and function of mucin 1, reveals its expression in human tumors, focuses on mucin 1-based targeted therapy regimens, and summarizes the research progress of mucin 1 in targeted tumor therapy.

引用

页码：1 / 17

页数：17

共 79 条

[21] MUC1 and maltose-binding protein recombinant fusion protein combined with Bacillus Calmette-Guerin induces MUC1-specific and nonspecific anti-tumor immunity in mice [J].

Fang, Fang ;

Ma, Jichun ;

Ni, Weihua ;

Wang, Fengli ;

Sun, Xiaxia ;

Li, Yingying ;

Li, Qiongshu ;

Xie, Fei ;

Wang, Juan ;

Zhai, Ruiping ;

Liu, Zhonghui ;

Gao, Sunjun ;

Tai, Guixiang .

MOLECULAR MEDICINE REPORTS, 2014, 10 (02) :1056-1064

[22] MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer [J].

Fu Xiao ;

Tang Neng ;

Xie Wei-Qi ;

Mao Liang ;

Qiu Yu-Dong .

CHINESE JOURNAL OF NATURAL MEDICINES, 2020, 18 (03) :178-185

[23] Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas [J].

Ghasemi, Zahra ;

Dinarvand, Rassoul ;

Mottaghitalab, Fatemeh ;

Esfandyari-Manesh, Mehdi ;

Sayari, Elmira ;

Atyabi, Fatemeh .

CARBOHYDRATE POLYMERS, 2015, 121 :190-198

[24]

Gilewski T, 2000, CLIN CANCER RES, V6, P1693

[25] A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells [J].

Glaffig, Markus ;

Stergiou, Natascha ;

Hartmann, Sebastian ;

Schmitt, Edgar ;

Kunz, Horst .

CHEMMEDCHEM, 2018, 13 (01) :25-29

[26] DF3 epitope expression on MUC1 mucin is associated with tumor aggressiveness, subsequent lymph node metastasis, and poor prognosis in patients with oral squamous cell carcinoma [J].

Hamada, Tomofumi ;

Nomura, Masahiro ;

Kamikawa, Yoshiaki ;

Yamada, Norishige ;

Batra, Surinder K. ;

Yonezawa, Suguru ;

Sugihara, Kazumasa .

CANCER, 2012, 118 (21) :5251-5264

[27] A calicheamicin conjugate with a fully humanized anti-MUC1 antibody shows potent antitumor effects in breast and ovarian tumor xenografts [J].

Hamann, PR ;

Hinman, LM ;

Beyer, CF ;

Lindh, D ;

Upeslacis, J ;

Shochat, D ;

Mountain, A .

BIOCONJUGATE CHEMISTRY, 2005, 16 (02) :354-360

[28] MUC1 aptamer-conjugated mesoporous silica nanoparticles effectively target breast cancer cells [J].

Hanafi-Bojd, Mohammad Yahya ;

Kalat, Seyedeh Alia Moosavian ;

Taghdisi, Seyed Mohammad ;

Ansari, Legha ;

Abnous, Khalil ;

Malaekeh-Nikouei, Bizhan .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 44 (01) :13-18

[29] Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling) [J].

Hanson, Ryan L. ;

Hollingsworth, Michael A. .

BIOMOLECULES, 2016, 6 (03)

[30] Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer [J].

Heublein, Sabine ;

Page, Sabina ;

Mayr, Doris ;

Schmoeckel, Elisa ;

Trillsch, Fabian ;

Marme, Frederik ;

Mahner, Sven ;

Jeschke, Udo ;

Vattai, Aurelia .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (02)

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