Advances in the Applications of Mucin 1 in Cancer Therapy

被引：1

作者：

Yang, Ben ^{[1
]}

Li, Hanyue ^{[1
]}

Wang, Fei ^{[1
]}

Zuo, Changjun ^{[1
]}

Qi, Yicheng ^{[1
]}

Song, Tiantian ^{[1
]}

Sun, Sipeng ^{[1
]}

Kou, Rongguan ^{[1
]}

Wang, Anping ^{[1
]}

Wang, Hui ^{[1
]}

Shi, Mengqi ^{[1
]}

Yu, Wenjing ^{[1
]}

Wang, Yubing ^{[1
]}

Gao, Zhiqin ^{[1
]}

机构：

[1] Weifang Med Univ, Shandong Univ Key Lab Biopharmaceut, Sch Life Sci & Technol, Weifang 261053, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2022年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mucin; 1; Cancer; Target; Glycosylation; Anti-Tumor; Copyright; American; TARGETED DRUG-DELIVERY; MONOCLONAL-ANTIBODY; ANTITUMOR IMMUNITY; T-CELLS; BREAST; EXPRESSION; VACCINE; NANOPARTICLES; METASTASIS; IMMUNOTHERAPY;

D O I：

10.1166/jbn.2023.3493

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation. Mucin 1 is weakly O-glycosylated in tumor cells, the core site is exposed, and it is widely distributed on the surface of tumor cells, making it an important tumor marker. Mucin 1 has a wide range of applications in tumor diagnosis, tumor drug targeted delivery, and immunodeficiency therapy. Animal studies and clinical studies suggest that mucin 1 can be used as a target in tumor-targeted therapy. This review covers our current summary of the structure and function of mucin 1, reveals its expression in human tumors, focuses on mucin 1-based targeted therapy regimens, and summarizes the research progress of mucin 1 in targeted tumor therapy.

引用

页码：1 / 17

页数：17

共 79 条

[1]

Agrawal B, 1998, CANCER RES, V58, P4079

[2] Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis [J].