Pathophysiology and Imaging Findings of COVID-19 Infection: An Organ-system Based Review

被引：15
作者：
Capaccione, K. M. [1 ]
Yang, H. [1 ]
West, E. [1 ]
Patel, H. [1 ]
Ma, H. [1 ]
Patel, S. [1 ]
Fruauff, A. [1 ]
Loeb, G. [1 ]
Maddocks, A. [1 ]
Borowski, A. [1 ]
Lala, S. [1 ]
Nguyen, P. [1 ]
Lignelli, A. [1 ]
D'souza, B. [1 ]
Desperito, E. [1 ]
Ruzal-Shapiro, C. [1 ]
Salvatore, M. M. [1 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Dept Radiol, 622 168th St, New York, NY 10032 USA
来源：
ACADEMIC RADIOLOGY | 2021年 / 28卷 / 05期
关键词：
COVID-19; SARS-CoV-2; thrombosis; ACE2; cytokine storm; imaging; inflammation; DISEASE; 2019; COVID-19; CT FINDINGS; INVOLVEMENT; MANIFESTATIONS; PNEUMONIA; ADULT;
D O I：
10.1016/j.acra.2021.01.022
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Background: COVID-19 commonly presents with upper respiratory symptoms; however, studies have shown that SARS-CoV-2 infection affects multiple organ systems. Here, we review the pathophysiology and imaging characteristics of SARS-CoV-2 infection in organ systems throughout the body and explore commonalities. Objective: Familiarity with the underlying pathophysiology and imaging characteristics is essential for the radiologist to recognize these findings in patients with COVID-19 infection. Though pulmonary findings are the most prevalent presentation, COVID-19 may have multiple manifestations and recognition of the extrapulmonary manifestations is especially important because of the potential serious and long-term effects of COVID-19 on multiple organ systems.
引用
收藏
页码：595 / 607
页数：13
相关论文
共 108 条
  • [1] Possible radiologic renal signs of COVID-19
    Akin, Isil Basara
    Altay, Canan
    Kutsoylu, Oya Eren
    Secil, Mustafa
    [J]. ABDOMINAL RADIOLOGY, 2021, 46 (02) : 692 - 695
  • [2] Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke
    Al Saiegh, Fadi
    Ghosh, Ritam
    Leibold, Adam
    Avery, Michael B.
    Schmidt, Richard F.
    Theofanis, Thana
    Mouchtouris, Nikolaos
    Philipp, Lucas
    Peiper, Stephen C.
    Wang, Zi-Xuan
    Rincon, Fred
    Tjoumakaris, Stavropoula, I
    Jabbour, Pascal
    Rosenwasser, Robert H.
    Gooch, M. Reid
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2020, 91 (08) : 846 - 848
  • [3] COVID-19 presenting as acute pancreatitis
    Aloysius, Mark M.
    Thatti, Ashwin
    Gupta, Anjalika
    Sharma, Nishant
    Bansal, Pardeep
    Goyal, Hemant
    [J]. PANCREATOLOGY, 2020, 20 (05) : 1026 - 1027
  • [4] COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
    Amraei, Razie
    Rahimi, Nader
    [J]. CELLS, 2020, 9 (07)
  • [5] Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State
    Arentz, Matt
    Yim, Eric
    Klaff, Lindy
    Lokhandwala, Sharukh
    Riedo, Francis X.
    Chong, Maria
    Lee, Melissa
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16): : 1612 - 1614
  • [6] Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series
    Argenziano, Michael G.
    Bruce, Samuel L.
    Slater, Cody L.
    Tiao, Jonathan R.
    Baldwin, Matthew R.
    Barr, R. Graham
    Chang, Bernard P.
    Chau, Katherine H.
    Choi, Justin J.
    Gavin, Nicholas
    Goyal, Parag
    Mills, Angela M.
    Patel, Ashmi A.
    Romney, Marie-Laure S.
    Safford, Monika M.
    Schluger, Neil W.
    Sengupta, Soumitra
    Sobieszczyk, Magdalena E.
    Zucker, Jason E.
    Asadourian, Paul A.
    Bell, Fletcher M.
    Boyd, Rebekah
    Cohen, Matthew F.
    Colquhoun, MacAlistair I.
    Colville, Lucy A.
    de Jonge, Joseph H.
    Dershowitz, Lyle B.
    Dey, Shirin A.
    Eiseman, Katherine A.
    Girvin, Zachary P.
    Goni, Daniella T.
    Harb, Amro A.
    Herzik, Nicholas
    Householder, Sarah
    Karaaslan, Lara E.
    Lee, Heather
    Lieberman, Evan
    Ling, Andrew
    Lu, Ree
    Shou, Arthur Y.
    Sisti, Alexander C.
    Snow, Zachary E.
    Sperring, Colin P.
    Xiong, Yuqing
    Zhou, Henry W.
    Natarajan, Karthik
    Hripcsak, George
    Chen, Ruijun
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2020, 369
  • [7] Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells
    Azizi, Sayed Ausim
    Azizi, Saara-Anne
    [J]. JOURNAL OF NEUROVIROLOGY, 2020, 26 (05) : 631 - 641
  • [8] Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19
    Azkur, Ahmet Kursat
    Akdis, Mubeccel
    Azkur, Dilek
    Sokolowska, Milena
    van de Veen, Willem
    Bruggen, Marie-Charlotte
    O'Mahony, Liam
    Gao, Yadong
    Nadeau, Kari
    Akdis, Cezmi A.
    [J]. ALLERGY, 2020, 75 (07) : 1564 - 1581
  • [9] Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms
    Baig, Abdul Mannan
    Khaleeq, Areeba
    Ali, Usman
    Syeda, Hira
    [J]. ACS CHEMICAL NEUROSCIENCE, 2020, 11 (07): : 995 - 998
  • [10] ST-Segment Elevation in Patients with Covid-19-A Case Series
    Bangalore, Sripal
    Sharma, Atul
    Slotwiner, Alexander
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) : 2478 - 2480
12345678910