Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

被引:5
作者
Huang, Jui-Hua [1 ,2 ]
Li, Ren-Hau [3 ]
Huang, Shu-Ling [3 ,4 ]
Sia, Hon-Ke [5 ,6 ]
Yu, Chao-Hung [7 ]
Tang, Feng-Cheng [8 ,9 ,10 ]
机构
[1] Chaoyang Univ Technol, Dept Golden Ager Ind Management, Taichung 413, Taiwan
[2] Changhua Christian Hosp, Occupat Hlth Ctr, Changhua 500, Taiwan
[3] Chung Shan Med Univ, Dept Psychol, Taichung 402, Taiwan
[4] Chung Shan Med Univ Hosp, Room Clin Psychol, Taichung 402, Taiwan
[5] Changhua Christian Hosp, Div Endocrinol & Metab, Changhua 500, Taiwan
[6] Asia Univ, Dept Healthcare Adm, 500 Lioufong Rd, Taichung 41354, Taiwan
[7] Changhua Christian Hosp, Dept Internal Med, Div Cardiovasc Med, Changhua 500, Taiwan
[8] Chaoyang Univ Technol, Dept Leisure Serv Management, Taichung 413, Taiwan
[9] Changhua Christian Hosp, Dept Occupat Med, Changhua 500, Taiwan
[10] Kaohsiung Med Univ, Sch Med, Kaohsiung 807, Taiwan
关键词
Framingham Risk Score; high-sensitivity C-reactive protein; white blood cell; serum uric acid; cardiovascular disease; gender; C-REACTIVE PROTEIN; BLOOD-CELL COUNT; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; ALL-CAUSE; MORTALITY; PREVENTION; CONSUMPTION; PREVALENCE; PREDICTION;
D O I
10.3390/ijerph18137103
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The purpose of the present study was to explore the role of gender in the relation of high-sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, and serum uric acid (UA) to the risk of future cardiovascular disease (CVD) events. In total, 404 workers were recruited to obtain the measurements of serum markers for CVD risk. Demographic data, nutrition, exercise, smoking, and alcohol consumption were assessed through a questionnaire. The Framingham Risk Score (FRS) was adopted to estimate the risk of future CVD events. Multiple linear regression models were used to determine CVD risk markers in relation to the FRS by gender. The hsCRP was not significantly correlated with the FRS for all workers after adjusting for covariates, including demographic data and health-related lifestyle. WBC count was positively correlated with FRS for all workers, but WBC count did not show an interaction with gender with respect to the FRS. Serum UA showed an interaction with gender on the FRS, and UA positively correlated with the FRS in males though not in females. With respect to CVD prevention, the WBC count can be used to monitor the risk for all workers. Due to a gender difference shown in the relationship between serum UA and the FRS, serum UA can be a monitor of the risk of future CVD events in male workers only.
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页数:10
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