Base damage and single-strand break repair: Mechanisms and functional significance of short- and long-patch repair subpathways

被引：219

作者：

Fortini, Paola ^{[1
]}

Dogliotti, Eugenia ^{[1
]}

机构：

[1] Ist Super Sanita, Sect Mol Epidemiol, Dept Environm & Primary Prevent, I-00161 Rome, Italy

来源：

DNA REPAIR | 2007年 / 6卷 / 04期

关键词：

base damage; dase excision repair; short and long-patch repair;

D O I：

10.1016/j.dnarep.2006.10.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A large variety of DNA lesions induced by environmental agents or arising as an outcome of cellular metabolism are counteracted by a complex network of proteins that belong to the base excision repair/single strand break repair (BER/SSBR) processes. No matter whether the initial lesions are modified DNA bases or single-strand breaks with non-conventional termini these processes are completed either by replacement of a single (short-patch, SP) or more (long-patch, LP) nucleotides by different arrays of proteins. Here, the factors that are involved in the selection between SP- and LP-BER/SSBR are reviewed. The biological significance of these alternative subpathways is also presented as inferred from mutant mouse/cell models. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：398 / 409

页数：12

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