Protein methylation and DNA repair

被引：43

作者：

Lake, Aimee N. ^{[1
]}

Bedford, Mark T. ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Div Sci Pk Res, Smithville, TX 78957 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2007年 / 618卷 / 1-2期

关键词：

arginine methylation; lysine methylation; tudor domain; chromo domain; P53; 53BP1; PHF20;

D O I：

10.1016/j.mrfmmm.2006.09.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA is under constant attack from intracellular and external mutagens. Sites of DNA damage need to be pinpointed so that the DNA repair machinery can be mobilized to the proper location. The identification of damaged sites, recruitment of repair factors, and assembly of repair "factories" is orchestrated by posttranslational modifications (PTMs). These PTMs include phosphorylation, ubiquitination, sumoylation, acetylation, and methylation. Here we discuss recent data surrounding the roles of arginine and lysine methylation in DNA repair processes. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：91 / 101

页数：11

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