Antigonadotrophic effect of Mycobacterium tuberculosis

被引：11
|
作者：
Kumar, A [1 ]
Rattan, A [1 ]
机构：
[1] ALL INDIA INST MED SCI,DEPT MICROBIOL,NEW DELHI 110029,INDIA
来源：
HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 10期
关键词：
progesterone; granulosa cells; Mycobacterium tuberculosis; ovary; tuberculosis; steroidogenesis;
D O I：
10.1055/s-2007-979088
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The present investigation has been carried out to study if the Mycobacterium tuberculosis has any direct effect on granulosa cell progesterone production. Granulosa cells from pregnant mare serum gonadotropin (PMSG)-treated immature rats were incubated in replicates with and without the ultrasonicated Mycobacterium tuberculosis in the presence and absence of human chorionic gonadotrophin (hCG). Progesterone production and granulosa cell viability were assayed. The mycobacterial lysate significantly inhibited the basal production of progesterone. The lysate completely blocked the stimulatory effect of hCG. Any cytotoxic effect of the lysate was ruled out as none of the treatments decreased the viability of the granulosa cells as compared with the control values.
引用
收藏
页码：501 / 503
页数：3
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