Toll-like receptor signalling through macromolecular protein complexes

被引：64

作者：

Bryant, Clare E. ^{[1
]}

Symmons, Martyn ^{[1
]}

Gay, Nicholas J. ^{[2
]}

机构：

[1] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

MOLECULAR IMMUNOLOGY | 2015年 / 63卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Toll-like receptor 4; Myddosome; SUBCELLULAR SITES; STRUCTURAL BASIS; TRANSDUCTION; ACTIVATION; RECOGNITION; RECRUITMENT; IRAK-4; MYD88; DIMER;

D O I：

10.1016/j.molimm.2014.06.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular mechanisms by which pattern recognition receptors (PRRs) signal are increasingly well understood. Toll-like receptor 4 (TLR4) signals through two separate pairs of adaptor proteins Mal/MyD88 and Tram/Trif. Structural studies have revealed a common theme for PRR signalling in that their signalling proteins form large macromolecular complexes which are thought to form the active signalling complex. The first of these to be characterised was the MyD88 signalling complex Myddosome. Many questions remain unanswered however. In particular it is unclear whether these signalling complexes form within the living cell, how many of each signalling protein is within the intracellular Myddosome and whether the stoichiometry can vary in a ligand-dependent manner. In this review we will discuss what is known about the macromolecular complexes thought to be important for TLR4 signalling. (C) 2014 Elsevier Ltd. All rights reserved.

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收藏

页码：162 / 165

页数：4

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