Folic acid supramolecular ionogels

Herein, we report on folic acid (FA, a low molecular weight gelator) thermoreversible supramolecular organo (in 1 : 1 (v/v) water-DMSO binary solvent), and ionogels made in 1-ethyl-3-methyl imidazolium chloride, [C2mim][Cl], and 1-octyl-3-methyl imidazolium chloride, [C8mim][Cl], solutions with 0.1 <= [IL] <= 5% (w/v). The self-assembled fibrils of folic acid were largely formed due to secondary forces, such as pi-pi stacking, H-bonding, and hydrophobic interactions above a gelator concentration of 0.2% (w/v) at room temperature, 20 degrees C. Fragile gels (FGs) having a low frequency storage modulus G(0) approximate to 4-6 Pa were formed when 0.2 < [FA] < 0.5% (w/v) in the binary solvent, and at higher gelator concentration (0.5 < [FA] <= 2.5% (w/v)) formation of strong gels (SGs) with a G(0) value of 140 Pa-5 kPa was noticed. In the IL environment, for a given gelator concentration of [FA] = 1% (w/v), SG formation (with G(0) approximate to 2-5 kPa) was noticed when 0.1 <= [IL] <= 0.5% (w/v), whereas very strong gels (VSGs) with remarkably high gel strengths were formed with G(0) approximate to 11-15 kPa. Gelation temperature T-gel could be varied from 45 to 75 degrees C by varying the FA concentration in the binary solvent, whereas the ionogels exhibited an almost 10 degrees C rise in gelation temperature. The information obtained from the relative network density nu(r) (ratio of network density in iono- to organo gel), differential free-energy and enthalpy of gelation, Delta G(W-IL) and Delta HW-IL (difference in free-energy and enthalpy of organo to ionogel), implied that [C2mim][Cl] ionogels had enhanced homogeneity, and higher crosslink density and gel strength. A 3-D plot of T-gel and G(0) versus gelator concentration clearly defines a phase diagram that describes the contour of the gelation domains of this biologically important gelator.