Modelling efforts needed to advance herpes simplex virus (HSV) vaccine development: Key findings from the World Health Organization Consultation on HSV Vaccine Impact Modelling

被引：38

作者：

Gottlieb, Sami L. ^{[1
]}

Giersing, Birgitte ^{[1
]}

Boily, Marie-Claude ^{[2
]}

Chesson, Harrell ^{[3
]}

Looker, Katharine J. ^{[4
]}

Schiffer, Joshua ^{[5
]}

Spicknall, Ian ^{[3
]}

Hutubessy, Raymond ^{[1
]}

Broutet, Nathalie ^{[1
]}

Deal, Carolyn ^{[6
]}

Gift, Thomas ^{[7
]}

Mogasale, Vittal ^{[8
]}

Moorthy, Vasee ^{[1
]}

Ndowa, Francis ^{[9
]}

Teerawattananon, Yot ^{[10
]}

Vickerman, Peter ^{[4
]}

Williams, Brian ^{[11
,12
]}

机构：

[1] WHO, Geneva, Switzerland

[2] Imperial Coll, London, England

[3] Ctr Dis Control & Prevent, CDC, Atlanta, GA USA

[4] Univ Bristol, Bristol, Avon, England

[5] Univ Washington, Seattle, WA 98195 USA

[6] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA

[7] CDC, Atlanta, GA 30333 USA

[8] Int Vaccine Inst, Seoul, South Korea

[9] Skin & GU Med Clin, Harare, Zimbabwe

[10] Minist Publ Hlth, Hlth Intervent & Technol Assessment Program, Bangkok, Thailand

[11] South African Ctr Epidemiol Modelling & Anal, Stellenbosch, South Africa

[12] Univ Witwatersrand, Wits Reprod Hlth Inst, Johannesburg, South Africa

来源：

VACCINE | 2019年 / 37卷 / 50期

关键词：

Herpes simplex virus; Sexually transmitted infections; HSV vaccines; Modelling; SEXUALLY-TRANSMITTED INFECTIONS; COST-EFFECTIVENESS; GENITAL HERPES; ANTIVIRAL THERAPY; HIV ACQUISITION; TYPE-2; TRANSMISSION; WOMEN; EPIDEMIOLOGY; PREVENTION;

D O I：

10.1016/j.vaccine.2017.03.074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of a vaccine against herpes simplex virus (HSV) is an important goal for global sexual and reproductive health. In order to more precisely define the health and economic burden of HSV infection and the theoretical impact and cost-effectiveness of an HSV vaccine, in 2015 the World Health Organization convened an expert consultation meeting on HSV vaccine impact modelling. The experts reviewed existing model-based estimates and dynamic models of HSV infection to outline critical future modelling needs to inform development of a comprehensive business case and preferred product characteristics for an HSV vaccine. This article summarizes key findings and discussions from the meeting on modelling needs related to HSV burden, costs, and vaccine impact, essential data needs to carry out those models, and important model components and parameters. (C) 2017 Published by Elsevier Ltd.

引用

页码：7336 / 7345

页数：10

共 51 条

[1] Genital Herpes Has Played a More Important Role than Any Other Sexually Transmitted Infection in Driving HIV Prevalence in Africa [J].