Infrared-active quadruple contrast FePt nanoparticles for multiple scale molecular imaging

被引：22

作者：

Chou, Shang-Wei ^{[1
]}

Liu, Chien-Liang ^{[1
]}

Liu, Tzu-Ming ^{[2
,3
]}

Shen, Yu-Fang ^{[2
,3
,4
]}

Kuo, Lun-Chang ^{[2
,3
]}

Wu, Cheng-Ham ^{[2
,3
]}

Hsieh, Tsung-Yuan ^{[2
,3
]}

Wu, Pei-Chun ^{[2
,3
]}

Tsai, Ming-Rung ^{[2
,3
]}

Yang, Che-Chang ^{[5
]}

Chang, Kai-Yao ^{[5
]}

Lu, Meng-Hua ^{[6
]}

Li, Pai-Chi ^{[7
]}

Chen, Shi-Ping ^{[7
]}

Wang, Yu-Hsin ^{[7
]}

Lu, Chen-Wen ^{[8
]}

Chen, Yi-An ^{[1
]}

Huang, Chih-Chia ^{[9
]}

Wang, Churng-Ren Chris ^{[10
]}

Hsiao, Jong-Kai ^{[8
]}

Li, Meng-Lin ^{[5
,6
]}

Chou, Pi-Tai ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan

[2] Natl Taiwan Univ, Inst Biomed Engn, Taipei 10617, Taiwan

[3] Natl Taiwan Univ, Mol Imaging Ctr, Taipei 10617, Taiwan

[4] China Med Univ Hosp, Printing Med Res Ctr 3D, Taichung, Taiwan

[5] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 30013, Taiwan

[6] Natl Tsing Hua Univ, Inst Photon Technol, Hsinchu 30013, Taiwan

[7] Natl Taiwan Univ, Dept Elect Engn, Taipei 10617, Taiwan

[8] Taipei TzuChi Hosp, Dept Med Imaging, Buddhist Tzuchi Med Fdn, New Taipei 23142, Taiwan

[9] Natl Cheng Kung Univ, Dept Photon, Tainan 701, Taiwan

[10] Natl Chung Cheng Univ, Dept Chem & Biochem, Minxiong 62102, Chia Yi County, Taiwan

来源：

BIOMATERIALS | 2016年 / 85卷

关键词：

FePt nanoparticle; Infrared-active; Multi-modality contrast; Multiphoton luminescence; Photoacoustic responses; Molecular imaging; ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; IN-VIVO; MULTIPHOTON MICROSCOPY; PHOTOACOUSTIC TOMOGRAPHY; MAGNETIC NANOPARTICLES; IRON-OXIDE; LUMINESCENCE; 3-PHOTON; SURFACE;

D O I：

10.1016/j.biomaterials.2016.01.053

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A single nanomaterial with multiple imaging contrasts and functions is highly desired for multiscale theragnosis. Herein, we demonstrate single 1-1.9 mu m infrared-active FePt alloy nanoparticles (FePt NPs) offering unprecedented four-contrast-in-one molecular imaging computed tomography (CT), magnetic resonance imaging (MRI), photoacoustic (PA) imaging, and high-order multiphoton luminescence (HOMPL) microscopy. The PA response of FePt NPs outperforms that of infrared-active gold nanorods by 3- to 5.6-fold under identical excitation fluence and particle concentrations. HOMPL (680 nm) of an isolated FePt NP renders spatial full-width-at-half-maximum values of 432 nm and 300 nm beyond the optical diffraction limit for 1230-nm and 920-nm excitation, respectively. The in vivo targeting function was successfully visualized using HOMPL, PA imaging, CT, and MRI, thereby validating FePt as a single nanomaterial system covering up to four types (Optical/PA/CT/MRI) of molecular imaging contrast, ranging from the microscopic level to whole-body scale investigation. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：54 / 64

页数：11

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