Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives

被引：161

作者：

Khursheed, Rubiya ^{[1
]}

Dua, Kamal ^{[2
,3
]}

Vishwas, Sukriti ^{[1
]}

Gulati, Monica ^{[1
,3
]}

Jha, Niraj Kumar ^{[4
]}

Aldhafeeri, Ghalib Mohammed ^{[5
]}

Alanazi, Fayez Ghadeer ^{[6
]}

Goh, Bey Hing ^{[7
,8
]}

Gupta, Gaurav ^{[9
,10
,11
]}

Paudel, Keshav Raj ^{[12
]}

Hansbro, Philip M. ^{[12
]}

Chellappan, Dinesh Kumar ^{[13
]}

Singh, Sachin Kumar ^{[1
,3
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[2] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW, Australia

[3] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia

[4] Sharda Univ, Sch Engn & Technol Set, Dept Biotechnol, Plot 32-34 Knowledge Pk 3, Greater Noida 201310, Uttar Pradesh, India

[5] Al Dawaa Med Serv, Hafar al Batin 39513, Saudi Arabia

[6] Lemon Pharm, Hafar al Batin 39957, Saudi Arabia

[7] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia

[8] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China

[9] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, Rajasthan, India

[10] Saveetha Univ, Saveetha Dent Coll, Saveetha Inst Med & Tech Sci, Dept Pharmacol, Chennai, Tamil Nadu, India

[11] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun 248007, Uttarakhand, India

[12] Centenary Inst & Univ Technol Sydney, Fac Sci, Ctr Inflammat, Sch Life Sci, Sydney, NSW 2007, Australia

[13] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 150卷

基金：

英国医学研究理事会;

关键词：

Cancer; Nanotechnology; Drug delivery; Metallic nanoparticles; MESOPOROUS SILICA NANOPARTICLES; ZINC-OXIDE NANOPARTICLES; LOADED MAGNETIC NANOPARTICLES; TARGETED DRUG-DELIVERY; SURFACE-PLASMON RESONANCE; GRAPHENE QUANTUM DOTS; ONE-POT SYNTHESIS; GOLD NANOPARTICLES; SILVER NANOPARTICLES; BREAST-CANCER;

D O I：

10.1016/j.biopha.2022.112951

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The current advancements in nanotechnology are as an outcome of the development of engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot of attention in biomedical field due to their significant inert nature, and nanoscale structures, with size similar to many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle characteristics such as size, shape, environment, aspect ratio, ease of synthesis and functionalization properties have led to numerous applications in various fields of biomedicine. These include targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, as well as the modulation of two or three applications. The current article also discusses about the various properties of metallic nanoparticles and their applications in cancer imaging and therapeutics. The associated bottlenecks related to their clinical translation are also discussed.

引用

页数：25

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