Prolonged Vastus Lateralis Denervation After Botulinum Toxin Type A Injection

被引：5

作者：

Dunne, John W. ^{[1
,2
]}

Singer, Barbara J. ^{[1
]}

Silbert, Peter L. ^{[1
,2
]}

Singer, Kevin P. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Surg, Ctr Musculoskeletal Studies, Perth, WA 6000, Australia

[2] Royal Perth Hosp, Dept Neurol, Perth, WA, Australia

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 03期

关键词：

botulinum A toxin; muscle denervation; electromyography; neuromuscular blockade; MUSCLE; DYSPORT(R); TERMINALS;

D O I：

10.1002/mds.22852

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intramuscular injection of botulinum toxin (BoNT) produces reversible blockade of neuromuscular transmission. In animal experimental models, recovery begins within four weeks and is usually complete by twelve weeks. We present evidence of prolonged denervation following BoNT injection of the vastus lateralis (VL) muscle to correct quadriceps muscle imbalance in patients with chronic anterior knee pain. Needle electromyography data were obtained from 10 subjects who had received a single BoNT treatment 5 to 19 months earlier as part of a clinical trial. Insertional and spontaneous activity, recruitment, and motor unit action potentials were examined. Clear differences between the injected and non-injected VL muscles, which correlated with the time since injection, were identified in all subjects. All 10 subjects studied with needle EMG showed evidence of persisting denervation in the BoNT-A injected VL muscle beyond the period of neuromotor recovery expected from animal experimental studies. (C) 2010 Movement Disorder Society

引用

页码：397 / 401

页数：5