The RNA World: molecular cooperation at the origins of life

被引：354

作者：

Higgs, Paul G. ^{[1
,2
]}

Lehman, Niles ^{[3
]}

机构：

[1] McMaster Univ, Origins Inst, Hamilton, ON L8S 4M1, Canada

[2] McMaster Univ, Dept Phys & Astron, Hamilton, ON L8S 4M1, Canada

[3] Portland State Univ, Dept Chem, Portland, OR 97207 USA

来源：

NATURE REVIEWS GENETICS | 2015年 / 16卷 / 01期

关键词：

TEMPLATE-DIRECTED SYNTHESIS; IN-VITRO; PREBIOTIC SYNTHESIS; POLYMERASE RIBOZYME; DARWINIAN EVOLUTION; EUTECTIC PHASE; SELECTION; CATALYSIS; POLYMERIZATION; DNA;

D O I：

10.1038/nrg3841

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The RNA World concept posits that there was a period of time in primitive Earth's history - about 4 billion years ago - when the primary living substance was RNA or something chemically similar. In the past 50 years, this idea has gone from speculation to a prevailing idea. In this Review, we summarize the key logic behind the RNA World and describe some of the most important recent advances that have been made to support and expand this logic. We also discuss the ways in which molecular cooperation involving RNAs would facilitate the emergence and early evolution of life. The immediate future of RNA World research should be a very dynamic one.

引用

页码：7 / 17

页数：11

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