Oral Nigella sativa oil administration alleviates arsenic-induced redox imbalance, DNA damage, and metabolic and histological alterations in rat liver

被引:9
作者
Alam, Tauseef [1 ]
Rizwan, Sana [1 ]
Farooqui, Zeba [1 ]
Abidi, Subuhi [2 ]
Parwez, Iqbal [2 ]
Khan, Farah [1 ]
机构
[1] Aligarh Muslim Univ, Dept Biochem, Fac Life Sci, Aligarh 202002, UP, India
[2] Aligarh Muslim Univ, Dept Zool, Fac Life Sci, Aligarh 202002, UP, India
关键词
Sodium arsenate; Nigella sativa oil; Hepatotoxicity; Oxidative stress; Carbohydrate metabolism; BRUSH-BORDER MEMBRANE; CARBOHYDRATE-METABOLISM; OXIDATIVE STRESS; INDUCED NEPHROTOXICITY; INDUCED TOXICITY; GLUTATHIONE; ENZYMES; ACID; RESISTANCE; CISPLATIN;
D O I
10.1007/s11356-021-13493-6
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Arsenic, an omnipresent environmental contaminant, is regarded as a potent hepatotoxin. Nigella sativa oil (NSO) consumption has been shown to improve hepatic functions in various in vivo models of acute hepatic injury. The present study evaluates the protective efficacy of NSO against sodium arsenate (As)-induced deleterious alterations in the liver. Male Wistar rats were divided into four groups, namely, control, As, NSO, and AsNSO. After pre-treating rats in AsNSO and NSO groups with NSO (2 mL/kg bwt, orally) for 14 days, NSO treatment was further extended for 30 days, with and without As treatment (5 mg/kg bwt, orally), respectively. As induced an upsurge in serum ALT and AST activities indicating liver injury, as also confirmed by the histopathological findings. As caused significant alterations in the activities of membrane marker enzymes and carbohydrate metabolic enzymes, and in the vital components of antioxidant defense system. Marked DNA damage and hepatic arsenic accumulation were also observed in As-treated rats. Oral NSO administration ameliorated these deleterious alterations and improved overall hepatic antioxidant and metabolic status in As-treated rats. Prevention of oxidative damage could be the underlying mechanism of NSO-mediated protective effects. The results suggest that NSO could be a useful dietary supplement in the management of arsenic hepatotoxicity.
引用
收藏
页码:41464 / 41478
页数:15
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