Clinical application of blood biomarkers in cerebrovascular disease

被引：3
作者：
El Husseini, Nada [1 ]
Laskowitz, Daniel T. [1 ]
机构：
[1] Duke Univ, Sch Med, Dept Med Neurol, Durham, NC 27710 USA
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2010年 / 10卷 / 02期
关键词：
biomarker; diagnosis; inflammation; oxidative stress; prognosis; risk stratification; stroke; C-REACTIVE PROTEIN; NEURON-SPECIFIC ENOLASE; PREDICTS HEMORRHAGIC TRANSFORMATION; INTERCELLULAR-ADHESION MOLECULE-1; TRANSIENT ISCHEMIC ATTACK; FIBRILLARY ACIDIC PROTEIN; SERUM-FREE HEMOGLOBIN; VON-WILLEBRAND-FACTOR; ACUTE STROKE; EARLY-DIAGNOSIS;
D O I：
10.1586/ERN.09.151
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Identifying a biomarker or panel of biomarkers of cerebral ischemia would have a major impact on the care of stroke patients by facilitating early management decisions and individualization of care. Biochemical surrogates of cerebral ischemia might also play an important role by identifying relevant pathways for novel therapeutic strategies and by facilitating early clinical trials in cerebrovascular disease. Serum biomarkers related to pathways of hemostasis, oxidation and inflammation, or alterations in glial and neuronal proteins, have been identified but none have been recommended for routine clinical use. This review describes the most promising biomarkers of cerebrovascular disease and the context and limitations in which they have been studied.
引用
收藏
页码：189 / 203
页数：15
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