Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study

被引：39

作者：

Yan, Shumei ^{[1
,2
,3
]}

He, Fan ^{[4
]}

Gao, Bei ^{[5
]}

Wu, Huini ^{[6
]}

Li, Mei ^{[1
,2
,3
]}

Huang, Liyun ^{[1
,2
,3
]}

Liang, Jianzhong ^{[1
,2
,3
]}

Wu, Qiuliang ^{[1
,2
,3
]}

Li, Yong ^{[1
,2
,3
]}

机构：

[1] State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

[2] Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Ctr Canc, Dept Pathol, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[4] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA

[5] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[6] Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA

来源：

JOURNAL OF CANCER | 2016年 / 7卷 / 06期

关键词：

APOBEC3B; non-small-cell lung cancer; immunohistochemistry; prognosis; BREAST-CANCER; CYTIDINE DEAMINASES; DECREASED SURVIVAL; EXPRESSION; POLYMORPHISM; ACTIVATION; EVOLUTION; CARCINOMA; MUTATION; DELETION;

D O I：

10.7150/jca.14030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer ranks as the most common and lethal malignancy in America and worldwide. APOBEC3B is a newly identified DNA cytosine deaminase, which is supposed to function as a major source of DNA mutation in many different tumors. In this study, we combine the data of online databases and two hundred and twenty-one primary non-small-cell lung carcinoma (NSCLC) specimens from Sun Yat-sen University Cancer Center to investigate, for the first time, the clinical role of APOBEC3B in lung cancer. We found that the APOBEC3 expression was commonly elevated in NSCLC tissues and overexpression of APOBEC3B was correlated with unfavorable prognosis of the patients with NSCLC. Furthermore, APOBEC3B expression was associated with nodal status, TNM staging and adjuvant chemotherapy of the patients with NSCLC. Further research is warranted.

引用

页码：618 / 625

页数：8

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