Solid-phase synthesis of chiral modular ferrocene-based peptides

被引：46
|
作者：
Heinze, Katia [1 ]
Wild, Ute [1 ]
Beckmann, Manuela [1 ]
机构：
[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2007年 / 04期
关键词：
conformation analysis; hydrogen bonds; metallocenes; molecular modelling; solid-phase synthesis;
D O I：
10.1002/ejic.200600857
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ferrocene-containing tripeptides with one to two ferrocene building blocks were prepared by solid-phase peptide synthesis (SPPS) using Fmoc-protected 1'-aminoferrocene-1-carboxylic acid (Fca). The conformations of the tripeptides were analysed by spectroscopic and theoretical methods. The immobilised ferrocene compounds can be reversibly oxidised on-bead to positively charged peptides and were analysed for anion-binding affinities by a solid-phase binding assay. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
引用
收藏
页码：617 / 623
页数：7
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