Solid-phase synthesis of chiral modular ferrocene-based peptides

Ferrocene-containing tripeptides with one to two ferrocene building blocks were prepared by solid-phase peptide synthesis (SPPS) using Fmoc-protected 1'-aminoferrocene-1-carboxylic acid (Fca). The conformations of the tripeptides were analysed by spectroscopic and theoretical methods. The immobilised ferrocene compounds can be reversibly oxidised on-bead to positively charged peptides and were analysed for anion-binding affinities by a solid-phase binding assay. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)