Activity of (-)α-bisabolol against Leishmania infantum promastigotes

被引：35
|
作者：
Morales-Yuste, M. [2 ]
Morillas-Marquez, F. [2 ]
Martin-Sanchez, J. [2 ]
Valero-Lopez, A. [2 ]
Navarro-Moll, M. C. [1 ]
机构：
[1] Univ Granada, Dept Farmacol, Fac Farm, Granada, Spain
[2] Univ Granada, Dept Parasitol, Fac Farm, Granada, Spain
来源：
PHYTOMEDICINE | 2010年 / 17卷 / 3-4期
关键词：
Leishmania infantum; Promastigotes; (-)alpha-bisabolol; Pentamidine; RICH ESSENTIAL OIL; ANTILEISHMANIAL ACTIVITY; ANTIBACTERIAL; GENERATION; INHIBITION; TOXICITY; GROWTH;
D O I：
10.1016/j.phymed.2009.05.019
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Many of the drugs used to treat leishmaniasis are associated with numerous adverse effects. Agents of natural origin have shown activity against different parasites. With this background, an in vitro study was conducted on the activity of (-)alpha-bisabolol, the principal component of Chamomilla recutita essential oil, against Leishmania infantum promastigotes, the main species responsible for human leishmaniasis in Spain. At the two highest concentrations tested (1000 and 500 mu g/ml), (-)alpha-bisabolol and pentamidine (control agent) achieved 100% inhibition of L. infantum promastigote. These in vitro data can be considered promising in support of the therapeutic use of (-)alpha-bisabolol preparations to treat leishmaniasis caused by L. infantum species. (C) 2009 Elsevier GmbH. All rights reserved.
引用
收藏
页码：279 / 281
页数：3
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