Reactivity study of 1H-thieno[3,2-d][1,3]oxazine-2,4-dione toward the synthesis of bicyclic 3,4-dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione analogues

被引：15

作者：

Brouillette, Yann ^{[1
]}

Lisowski, Vincent ^{[1
]}

Fulcrand, Pierre ^{[1
]}

Martinez, Jean ^{[1
]}

机构：

[1] Univ Montpellier 2, UFR Sci Pharmaceut & Biol, CNRS, UMR 5810,LAPP, F-34093 Montpellier 5, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 07期

关键词：

EFFICIENT SYNTHESIS; RING; ANTAGONISTS; PREDICTION; DISCOVERY; KINETICS; XANTHINE; AGENTS;

D O I：

10.1021/jo0622882

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] A series of 10 optically pure 3,4-dihydro-1H-thieno[3,2-e][1,4]diazepine-2,5-dione derivatives has been synthesized in 41-75% yields on treatment of 1H-thieno[3,2-d][1,3]oxazine-2,4-dione with different natural alpha-amino acids.

引用

页码：2662 / 2665

页数：4

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