Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study
被引:172
作者:
Silberg, Judy L.
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机构:
Virginia Commonwealth Univ, Dept Human & Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USAVirginia Commonwealth Univ, Dept Human & Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
Silberg, Judy L.
[1
]
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机构:
Maes, Hermine
[1
]
Eaves, Lindon J.
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机构:
Virginia Commonwealth Univ, Dept Human & Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USAVirginia Commonwealth Univ, Dept Human & Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
Eaves, Lindon J.
[1
]
机构:
[1] Virginia Commonwealth Univ, Dept Human & Mol Genet, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
Children of Twins;
parental depression;
juvenile depression;
conduct disturbance;
genetic risk;
family environment;
MATERNAL DEPRESSION;
AFFECTIVE-DISORDERS;
VIRGINIA TWIN;
DEVELOPMENTAL PSYCHOPATHOLOGY;
MOTHERS;
CHILDHOOD;
BEHAVIOR;
STRESS;
SEX;
AGE;
D O I:
10.1111/j.1469-7610.2010.02205.x
中图分类号:
B844 [发展心理学(人类心理学)];
学科分类号:
040202 ;
摘要:
Background: Despite the increased risk of depression and conduct problems in children of depressed parents, the mechanism by which parental depression affects their children's behavioral and emotional functioning is not well understood. The present study was undertaken to determine whether parental depression represents a genuine environmental risk factor in children's psychopathology, or whether children's depression/conduct can be explained as a secondary consequence of the genetic liability transmitted from parents to their offspring. Methods: Children of Twins (COT) data collected on 2,674 adult female and male twins, their spouses, and 2,940 of their children were used to address whether genetic and/or family environmental factors best account for the association between depression in parents and depression and conduct problems in their children. Data collected on juvenile twins from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) were also included to estimate child-specific genetic and environmental influences apart from those effects arising from the transmission of the parental depression itself. The fit of alternative Children of Twin models were evaluated using the statistical program Mx. Results: The most compelling model for the association between parental and juvenile depression was a model of direct environmental risk. Both family environmental and genetic factors accounted for the association between parental depression and child conduct disturbance. Conclusions: These findings illustrate how a genetically mediated behavior such as parental depression can have both an environmental and genetic impact on children's behavior. We find developmentally specific genetic factors underlying risk to juvenile and adult depression. A shared genetic liability influences both parental depression and juvenile conduct disturbance, implicating child conduct disturbance (CD) as an early indicator of genetic risk for depression in adulthood. In summary, our analyses demonstrate differences in the impact of parental depression on different forms of child psychopathology, and at various stages of development.
机构:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USAVirginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USA
Silberg, JL
Eaves, LJ
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机构:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USAVirginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USA
机构:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USAVirginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USA
Silberg, JL
Eaves, LJ
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h-index: 0
机构:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USAVirginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Sch Med, Dept Human Genet, Richmond, VA 23298 USA