TGF-β signaling and its functional significance in regulating the fate of cranial neural crest cells

被引：58
作者：
Chai, Y [1 ]
Ito, Y [1 ]
Han, J [1 ]
机构：
[1] Univ So Calif, Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA
来源：
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE | 2003年 / 14卷 / 02期
关键词：
cranial neural crest (CNC) cells; Msx; Smads; TGF-beta; TGF-beta receptors; tooth;
D O I：
10.1177/154411130301400202
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Members of the transforming growth factor-beta (TGF-beta) superfamily regulate cell proliferation, differentiation, and apoptosis, and control the development and maintenance of most tissues. TGF-beta signal is transmitted through the phosphorylation of Smad proteins by TGF-beta receptor serine/threonine kinase. During craniofacial development, TGF-beta may regulate the fate specification of cranial neural crest cells. These cells are multipotent progenitors and capable of producing diverse cell types upon differentiation. Here we summarize evidence that TGF-beta ligands and their signaling intermediates have significant roles in patterning and specification of cranial neural crest cells. The biological function of TGF-beta is carried out through the regulation of transcriptional factors during embryogenesis.
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收藏
页码：78 / 88
页数：11
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