Stroke prevention in sickle cell disease

被引：19

作者：

Adams, RJ ^{[1
]}

机构：

[1] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2000年 / 7卷 / 02期

关键词：

D O I：

10.1097/00062752-200003000-00005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurological complications, especially stroke, have long been recognized in sickle cell disease. Advances in care have increased the life expectancy of such patients, and recent information has better established the epidemiology of stroke. Prevention of stroke in children has been established in a clinical trial. Silent brain lesions revealed by MRI are common and are associated with impairments of cognitive function. Transfusion remains the primary mode of prevention and treat ment for stroke, although interest is increasing in hydroxyurea; however, there are no data regarding its efficacy. (C) 2000 Lippincott Williams & Wilkins, Inc.

引用

页码：101 / 105

页数：5

共 26 条

[1] THE USE OF TRANSCRANIAL ULTRASONOGRAPHY TO PREDICT STROKE IN SICKLE-CELL DISEASE [J].

ADAMS, R ;

MCKIE, V ;

NICHOLS, F ;

CARL, E ;

ZHANG, DL ;

MCKIE, K ;

FIGUEROA, R ;

LITAKER, M ;

THOMPSON, W ;

HESS, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (09) :605-610

[2] Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler [J].

Adams, RJ ;

McKie, VC ;

Carl, EM ;

Nichols, FT ;

Perry, R ;

Brock, K ;

McKie, K ;

Figueroa, R ;

Litaker, M ;

Weiner, S ;

Brambilla, D .

ANNALS OF NEUROLOGY, 1997, 42 (05) :699-704

[3] Prevention of a first stroke by transfusions in children with sickle, cell anemia and abnormal results on transcranial Doppler ultrasonography [J].

Adams, RJ ;

McKie, VC ;

Hsu, L ;

Files, B ;

Vichinsky, E ;

Pegelow, C ;

Abboud, M ;

Gallagher, D ;

Kutlar, A ;

Nichols, FT ;

Bonds, DR ;

Brambilla, D ;

Woods, G ;

Olivieri, N ;

Driscoll, C ;

Miller, S ;

Wang, W ;

Hurlett, A ;

Scher, C ;

Berman, B ;

Carl, E ;

Jones, AM ;

Roach, ES ;

Wright, E ;

Zimmerman, RA ;

Waclawiw, M ;

Pearson, H ;

Powars, D ;

Younkin, D ;

El-Gammal, T ;

Seibert, J ;

Moye, L ;

Espeland, M ;

Murray, R ;

McKinley, R ;

McKinley, S ;

Hagner, S ;

Weiner, S ;

Estow, S ;

Yelle, M ;

Brock, K ;

Carter, E ;

Chiarucci, K ;

Debarr, M ;

Feron, P ;

Harris, S ;

Hoey, L ;

Jacques, K ;

Kuisel, L ;

Lewis, N .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (01) :5-11

[4]

ADAMS RJ, 1989, HDB CLIN NEUROLOGY 3, V11, P503

[5]

Armstrong FD, 1996, PEDIATRICS, V97, P864

[6] EFFECT OF HYDROXYUREA ON THE FREQUENCY OF PAINFUL CRISES IN SICKLE-CELL-ANEMIA [J].

CHARACHE, S ;

TERRIN, ML ;

MOORE, RD ;

DOVER, GJ ;

BARTON, FB ;

ECKERT, SV ;

MCMAHON, RP ;

BONDS, DR ;

ORRINGER, E ;

JONES, S ;

STRAYHORN, D ;

ROSSE, W ;

PHILLIPS, G ;

PEACE, D ;

JOHNSONTELFAIR, A ;

MILNER, P ;

KUTLAR, A ;

TRACY, A ;

BALLAS, SK ;

ALLEN, GE ;

MOSHANG, J ;

SCOTT, B ;

STEINBERG, M ;

ANDERSON, A ;

SABAHI, V ;

PEGELOW, C ;

TEMPLE, D ;

CASE, E ;

HARRELL, R ;

CHILDERIE, S ;

EMBURY, S ;

SCHMIDT, B ;

DAVIES, D ;

KOSHY, M ;

TALISCHYZAHED, N ;

DORN, L ;

PENDARVIS, G ;

MCGEE, M ;

TELFER, M ;

DAVIS, A ;

CASTRO, O ;

FINKE, H ;

PERLIN, E ;

SITEMAN, J ;

GASCON, P ;

DIPAOLO, P ;

GARGIULO, S ;

ECKMAN, J ;

BAILEY, JH ;

PLATT, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1317-1322

[7]

FREMPONG KO, 1996, BLOOD, V91, P288

[8] Mechanisms of stroke in sickle cell disease: Sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition [J].

French, JA ;

Kenny, D ;

Scott, JP ;

Hoffmann, RG ;

Wood, JD ;

Hudetz, AG ;

Hillery, CA .

BLOOD, 1997, 89 (12) :4591-4599

[9] ABNORMAL HEMOGLOBIN AS A CAUSE OF NEUROLOGIC DISEASE [J].

GREER, M ;

SCHOTLAND, D .

NEUROLOGY, 1962, 12 (02) :114-&

[10] Homocysteine in sickle cell disease: Relationship to stroke [J].

Houston, PE ;

Rana, S ;

Sekhsaria, S ;

Perlin, E ;

Kim, KS ;

Castro, OL .

AMERICAN JOURNAL OF MEDICINE, 1997, 103 (03) :192-196

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