Guanine, Adenine, and Hypoxanthine Production in UV-Irradiated Formamide Solutions: Relaxation of the Requirements for Prebiotic Purine Nucleobase Formation

被引：149

作者：

Barks, Hannah L. ^{[1
]}

Buckley, Ragan ^{[1
]}

Grieves, Gregory A. ^{[1
]}

Di Mauro, Ernesto ^{[2
]}

Hud, Nicholas V. ^{[1
]}

Orlando, Thomas M. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[2] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 09期

关键词：

formamide; nitrogen heterocycles; photochemistry; prebiotic syntheses; purines; HYDROGEN CYANIDE; ORIGIN; BASES; ACIDS; EARTH; CODE; LIFE; HCN;

D O I：

10.1002/cbic.201000074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Relaxed requirements: We demonstrate the formation of adenine, hypoxanthine, and guanine from heated (130 °C), UV-irradiated formamide solutions in the absence of an inorganic catalyst. Evidence is also provided that classical" HCN pathways for purine nucleobase production are also active in heated and UV-irradiated formamide reactions. (Chemical Equation Presented) © 2010 Wiley-VCH Verlag GmbH& Co. KGaA."

引用

页码：1240 / 1243

页数：4

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