Multinucleation of spermatozoa and spermatids in infertile men chronically exposed to carbofuran

被引：8

作者：

Gallegos-Avila, Guadalupe ^{[1
]}

Ancer-Rodriguez, Jesus ^{[1
]}

Niderhauser-Garcia, Alberto ^{[1
]}

Ortega-Martinez, Marta ^{[1
]}

Jaramillo-Rangel, Gilberto ^{[1
]}

机构：

[1] Autonomous Univ Nuevo Leon, Sch Med, Dept Pathol, Monterrey, Nuevo Leon, Mexico

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 29卷 / 04期

关键词：

Multinucleation; Spermatozoa; Spermatids; Carbofuran; Infertile men; NONNEURONAL ACETYLCHOLINE;

D O I：

10.1016/j.reprotox.2010.03.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: To report the findings encountered in semen samples coming from two infertile men chronically exposed to carbofuran. Methods: Semen samples were collected and analyzed as recommended by the World Health Organization. A morphological analysis was carried out by light microscopy. Results: Seminal analysis revealed in the first case a total concentration of 42 million spermatozoa/mL with 17% motility and 20% normal shape. The second patient presented a total concentration of 5 million spermatozoa/mL with 6% motility and 2% normal shape. The patients presented a similar percentage of binucleated spermatozoa (28 and 26%) and of multinucleated spermatids (10 and 6%). Conclusion: To our knowledge, this is the first time that alterations in semen samples of men exposed to carbofuran are reported. More research in this area is needed to make conclusions on the subject. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：458 / 460

页数：3

共 15 条

[1] [Anonymous], 1999, WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction
[2] Induction of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure
Chauhan, LKS
Pant, N
Gupta, SK
Srivastava, SP
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2000, 465 (1-2) : 123 - 129
[3] Cole DC, 1998, J TOXICOL ENV HEAL A, V55, P77, DOI 10.1080/009841098158520
[4] CARBOFURAN TOXICITY
GUPTA, RC
[J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1994, 43 (04): : 383 - 418
[5] Sperm morphology, motility, and concentration in fertile and infertile men.
Guzick, DS
Overstreet, JW
Factor-Litvak, P
Brazil, CK
Nakajima, ST
Coutifaris, C
Carson, SA
Cisneros, P
Steinkampf, MP
Hill, JA
Xu, D
Vogel, DL
Natl Cooperative Reprod Med Network
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (19) : 1388 - 1393
[6] Ultrastructure of gametes and intracytoplasmic sperm injection:: the significance of sperm morphology
Küpker, W
Schulze, W
Diedrich, K
[J]. HUMAN REPRODUCTION, 1998, 13 : 99 - 106
[7] Anticholinesterase toxicity and oxidative stress
Milatovic, Dejan
Gupta, Ramesh C.
Aschner, Michael
[J]. THESCIENTIFICWORLDJOURNAL, 2006, 6 : 295 - 310
[8] Clinical evaluation of pesticide exposure and poisonings
OMalley, M
[J]. LANCET, 1997, 349 (9059) : 1161 - 1166
[9] EFFECT OF ORAL-ADMINISTRATION OF CARBOFURAN ON MALE REPRODUCTIVE-SYSTEM OF RAT
PANT, N
PRASAD, AK
SRIVASTAVA, SC
SHANKAR, R
SRIVASTAVA, SP
[J]. HUMAN & EXPERIMENTAL TOXICOLOGY, 1995, 14 (11): : 889 - 894
[10] In utero and lactational exposure of carbofuran to rats: Effect on testes and sperm
Pant, N
Shankar, R
Srivastava, SP
[J]. HUMAN & EXPERIMENTAL TOXICOLOGY, 1997, 16 (05): : 267 - 272

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