Ceiba pentandra cellulose crosslinked with citric acid for drug release systems

被引：10
|
作者：
Argelia Peraza-Ku, Silvia [1 ]
Escobar-Morales, Beatriz [2 ]
Rodriguez-Fuentes, Nayeli [3 ]
Manuel Cervantes-Uc, Jose [1 ]
Alonso Uribe-Calderon, Jorge [1 ]
机构：
[1] Ctr Invest Cient Yucatan, AC Unidad Mat, Calle 43 130 X 32 y 34, Merida 97205, Yucatan, Mexico
[2] Unidad Energia Renovable, Carretera Sierra Papacal Chuburna Puerto,Km 5, Papacal 97302, Yucatan, Mexico
[3] Consejo Nacl Ciencia & Technol, Lab Biomat, Calle 43 130 X 32 y 34, Merida 97205, Yucatan, Mexico
来源：
CARBOHYDRATE RESEARCH | 2021年 / 504卷
关键词：
Green crosslinking; Ceiba pentandra cellulose; Drug release; Citric acid; Chlorhexidine diacetate; CHLORHEXIDINE-DIGLUCONATE; MECHANICAL STRENGTH; KAPOK FIBER; LINKING;
D O I：
10.1016/j.carres.2021.108334
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An alternative for the production of drug delivery system is proposed based on the Ceiba pentandra milkweed. The kapok cellulose was chemically crosslinked with citric acid (CA) at different CA proportions, and loaded with chlorhexidine diacetate (CHX) at different concentrations. Cellulose crosslinking was followed with FTIR and XPS analysis, and the CHX loading was determined using elemental analysis. In vitro studies showed a burst release within the first 2-3 h and the drug release kinetics was described with several models. In addition, the crosslinked Ceiba pentandra fibers did not exhibit a cytotoxic effect on human dermic fibroblasts. Results indicate that the crosslinked Ceiba pentandra fibers are a feasible material for the production of systems for drug release applications.
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页数：8
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