Prenatal Treatment with Dexamethasone in Suspected Congenital Adrenal Hyperplasia and Orofacial Cleft: a Case Report and Review of the Literature

被引：7
作者：
Rijk, Yvonne [1 ]
van Alfen-van der Velden, JanieIle [1 ]
Claahsen-van der Grinten, Hedi L. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Amalia Childrens Hosp, Dept Pediat Endocrinol, Nijmegen, Netherlands
来源：
PEDIATRIC ENDOCRINOLOGY REVIEWS PER | 2017年 / 15卷 / 01期
关键词：
Congenital adrenal hyperplasia; Dexamethasone; Orofacial cleft; Pregnancy; Neonate; CORTICOSTEROID USE; TREATED CHILDREN; ORAL CLEFTS; FOLLOW-UP; RISK; PALATE; ANOMALIES; PREGNANCY; DIAGNOSIS; LIP;
D O I：
10.17458/per.vol15.2017.rvc.prenataltreatment
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is a genetic disorder that leads to hypocortisolism, hyperandrogenism and, in the most severe forms, also to hypoaldosteronism. Girls with classic CAH are born with virilized external genitalia. Prenatal dexamethasone (DXM) treatment can reduce virilization but may have side effects for mother and fetus. We present the first case of a girl who was born with CAH and an orofacial cleft. She was treated with prenatal DXM to prevent virilization. Oral clefts have to be considered as a potential side effect of prenatal DXM treatment.
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页码：21 / 25
页数：5
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