NRP1 function and targeting in neurovascular development and eye disease

被引：66
作者：
Raimondi, Claudio [1 ]
Brash, James T. [1 ]
Fantin, Alessandro [1 ]
Ruhrberg, Christiana [1 ]
机构：
[1] UCL, Inst Ophthalmol, 11-43 Bath St, London EC1V 9EL, England
来源：
PROGRESS IN RETINAL AND EYE RESEARCH | 2016年 / 52卷
基金：
英国惠康基金;
关键词：
Angiogenesis; Neovascularisation; Vascular permeability; Endothelial cell; Neuropilin; ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; OXYGEN-INDUCED RETINOPATHY; RETINAL GANGLION-CELLS; END-RULE PEPTIDES; VEGF-A BINDING; SEMAPHORIN; 3A; NEUROPILIN; IN-VIVO; CYTOPLASMIC DOMAIN;
D O I：
10.1016/j.preteyeres.2016.02.003
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 function, and a multitude of therapeutics targeting NRP1 have been designed, mostly with the view to explore them for cancer treatment. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1, with particular focus on neuronal and vascular roles in the brain and retina. This review will also discuss the potential of NRP1 inhibitors for the treatment for neovascular eye diseases. (C) 2016 The Authors. Published by Elsevier Ltd.
引用
收藏
页码：64 / 83
页数：20
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