Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane

被引:95
作者
Brismar, H
Asghar, M
Carey, RM
Greengard, P
Aperia, A [1 ]
机构
[1] Karolinska Inst, Dept Woman & Child Hlth, Astrid Lindgrens Childrens Hosp, S-17176 Stockholm, Sweden
[2] Univ Virginia, Hlth Sci Ctr, Dept Med, Charlottesville, VA 22908 USA
[3] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA
关键词
D O I
10.1073/pnas.95.10.5573
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The recruitment of G protein-coupled receptors from the cytoplasm to the plasma membrane generally is believed to be a constitutive process. We show here by the use of both confocal microscopy and subcellular fractionation that, for at least one such receptor, this recruitment is regulated and not constitutive. Cells from a proximal tubular-like cell line, LLCPK1 cells, were incubated with either a D1 agonist, a dopamine precursor, or an inhibitor of dopamine metabolism to increase dopamine availability in the cell. Each of the three procedures led to a rapid translocation of dopamine D1 receptors from the cytosol to the plasma membrane.
引用
收藏
页码:5573 / 5578
页数:6
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