IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

被引：115

作者：

Bettelli, E

Kuchroo, VK

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 02期

关键词：

D O I：

10.1084/jem.20042279

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23-driven subset of Th cells called ThIL-17 has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23-induced ThIL-17 cells are a unique subset or are related to other Th subsets is discussed.

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页码：169 / 171

页数：3

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