Central bombesin inhibits food intake and the orexigenic effect of neuropeptide Y in the neonatal chick

被引：16

作者：

Bungo, T

Ando, R

Kawakami, SI

Ohgushi, A

Shimojo, M

Masuda, Y

Furuse, M ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Div Anim & Marine Bioresources Sci, Lab Feed Sci,Dept Anim Sci, Fukuoka 8128581, Japan

[2] Kyushu Natl Agr Expt Stn, Dept Anim Prod, Kumamoto 8611192, Japan

来源：

PHYSIOLOGY & BEHAVIOR | 2000年 / 70卷 / 05期

关键词：

bombesin; neuropeptide Y; central nervous system; feeding behavior; chicken;

D O I：

10.1016/S0031-9384(00)00301-2

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

It is well known that central injection of bombesin (BN) suppresses feeding in mammalian and avian species, but the anorexigenic effect of central BN are still open with special reference to the chick. The dose response (0, 0.1 and 0.5 mug) of intracerebroventricular (ICV) injection of BN was examined in Experiment 1. ICV injection of BN inhibited food intake in a dose-dependent manner. Experiment 2 was done to determine whether BN interacts with the orexigenic effect of neuropeptide Y (NPY) in the neonatal chick. Central administration of NPY (2.5 mug) greatly enhanced food intake, but co-injection of BN (0.5 mug) suppressed food intake. The dose response of NPY (2.5 mug) co-injected with three levels of BN (0, 0.1 and 0.5 Gig) was examined in Experiment 3. ICV injection of BN attenuated the hyperphagia by NPY in a dose-related fashion. It is suggested that central BN may interact with NPY for the regulation of feeding in the neonatal chick. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：573 / 576

页数：4

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