Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity

被引：16

作者：

Alyamkina, Ekaterina A. ^{[1
]}

Dolgova, Evgenia V. ^{[1
]}

Likhacheva, Anastasia S. ^{[2
]}

Rogachev, Vladimir A. ^{[2
]}

Sebeleva, Tamara E. ^{[2
]}

Nikolin, Valeriy P. ^{[1
,2
]}

Popova, Nelly A. ^{[1
,2
]}

Kiseleva, Elena V. ^{[2
]}

Orishchenko, Konstantin E. ^{[2
]}

Sakhno, Ludmila V. ^{[3
]}

Gel'fgat, Evgeniy L. ^{[3
]}

Ostanin, Alexandr A. ^{[3
]}

Chernykh, Elena R. ^{[3
]}

Zagrebelniy, Stanislav N. ^{[1
]}

Bogachev, Sergey S. ^{[2
]}

Shurdov, Mikhail A. ^{[4
]}

机构：

[1] Novosibirsk State Univ, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

[3] Russian Acad Med Sci, Siberian Branch, Inst Clin Immunol, Novosibirsk, Russia

[4] LLC Panagen, Gorno Altaisk, Russia

来源：

CELLULAR IMMUNOLOGY | 2010年 / 262卷 / 02期

关键词：

Nucleosome-free fragmented dsDNA; Mononuclear cells; Lung tuberculosis; Allostimulatory activity; HORIZONTAL TRANSFER; CPG DNA; ACTIVATION; RECOGNITION; INTERFERON; INNATE; DIFFERENTIATION; PLASMA/SERUM; NUCLEOSOMES; EXPRESSION;

D O I：

10.1016/j.cellimm.2010.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：120 / 126

页数：7

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