Clonal Diversity and Drug Resistance in Mycobacterium tuberculosis Isolated from Extra-pulmonary Samples in Central India - a Pilot Study

被引：7

作者：

Desikan, P. ^{[1
]}

Chauhan, D. S. ^{[2
]}

Sharma, P. ^{[2
]}

Panwalkar, N. ^{[1
]}

Yadav, P. ^{[2
]}

Ohri, B. S. ^{[3
]}

机构：

[1] Indian Council Med Res, Bhopal Mem Hosp & Res Ctr, Dept Microbiol, Bhopal, Madhya Pradesh, India

[2] Indian Council Med Res, Natl JALMA Inst Leprosy & other Mycobacterial Dis, Inst Leprosy & Other Mycobacterial Dis, Dept Microbiol & Mol Biol, Agra, Uttar Pradesh, India

[3] Directorate Hlth Serv, Bhavan, Madhya Pradesh, India

来源：

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY | 2014年 / 32卷 / 04期

关键词：

Central India; extrapulmonary; M; tuberculosis; spoligotyping; EXTRAPULMONARY; DIAGNOSIS;

D O I：

10.4103/0255-0857.142255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In India, extrapulmonary tuberculosis (EPTB) accounts for 10 - 15% of all types of tuberculosis. To identify and compare predominant spoligotypes and drug-resistance patterns in strains of Mycobacterium tuberculosis isolated from extrapulmonary and pulmonary specimens in central India, drug susceptibility testing and spoligotyping were carried out. Spoligotyping data was analyzed using SITVIT2 database. ST11/EAI3_Ind with 33% isolates among extrapulmonary specimens and ST26/CAS1_DEL with 28% isolates among pulmonary specimens were the most predominant lineages. Multidrug resistance was found in 5.5% of the strains isolated from extrapulmonary specimens in contrast to 17% isolated from pulmonary specimens.

引用

页码：434 / 437

页数：4

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