Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily

被引：63

作者：

Abramson, J ^{[1
]}

Kaback, HR

Iwata, S

机构：

[1] Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London SW7 2AZ, England

[2] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Physiol, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Microbiol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Immunol, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Mol Genet, Los Angeles, CA USA

[6] Univ London Imperial Coll Sci & Technol, Div Biomed Sci, London SW7 2AZ, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.sbi.2004.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural knowledge of the major facilitator superfamily has dramatically increased during the past year with the emergence of the structures of three members of this family of transporters. All three structures reveal 12 transmembrane helices forming two distinct domains, and could imply that members of this superfamily have preserved both secondary and tertiary structure elements during evolution.

引用

页码：413 / 419

页数：7

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