Role of autophagy in Caenorhabditis elegans

被引：35

作者：

Kovacs, Attila Lajos ^{[2
]}

Zhang, Hong ^{[1
]}

机构：

[1] Natl Inst Biol Sci, Beijing 102206, Peoples R China

[2] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, Cell Physiol Lab, Budapest, Hungary

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

关键词：

Autophagy; PGL granule; Caenorhabditis elegans; P GRANULE COMPONENTS; LIFE-SPAN EXTENSION; GERM GRANULES; DEFECTIVE-MUTANTS; AXONAL ELONGATION; CELL-DEATH; DEGRADATION; GENES; PROTEINS; KINASE;

D O I：

10.1016/j.febslet.2010.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is an evolutionarily conserved intracellular catabolic system. During Caenorhabditis elegans development, autophagy plays an important role in many physiological processes, including survival under starvation conditions, modulation of life span, and regulation of necrotic cell death caused by toxic ion-channel variants. Recently, it has been demonstrated that during embryogenesis, basal levels of autophagy selectively remove a group of proteins in somatic cells, including the aggregate-prone components of germline P granules. Degradation of these protein aggregates provides a genetic model to identify essential autophagy components and also to elucidate how the autophagic machinery selectively recognizes and degrades specific targets during animal development. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1335 / 1341

页数：7

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