Diabetic kidney disease: a clinical update from Kidney Disease: Improving Global Outcomes

被引:220
作者
Molitch, Mark E. [1 ]
Adler, Amanda I. [2 ]
Flyvbjerg, Allan [3 ]
Nelson, Robert G. [4 ]
So, Wing-Yee [5 ]
Wanner, Christoph [6 ]
Kasiske, Bertram L. [7 ]
Wheeler, David C. [8 ]
de Zeeuw, Dick [9 ]
Mogensen, Carl E. [10 ,11 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Div Endocrinol, Chicago, IL 60611 USA
[2] Addenbrookes Hosp, Inst Metab Sci, Cambridge, England
[3] Aarhus Univ, Aarhus, Denmark
[4] NIDDK, NIH, Phoenix, AZ USA
[5] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
[6] Univ Hosp Wurzburg, Wurzburg, Germany
[7] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA
[8] UCL, London, England
[9] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands
[10] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark
[11] Aarhus Univ, Aarhus, Denmark
关键词
albuminuria; blood pressure; diabetic kidney disease; glycemic control; lipid management; GLOMERULAR-FILTRATION-RATE; BLOOD-PRESSURE CONTROL; CARDIORENAL END-POINTS; STAGE RENAL-DISEASE; HIGH VASCULAR RISK; GLYCEMIC CONTROL; CYSTATIN C; ALL-CAUSE; COLLABORATIVE METAANALYSIS; CARDIOVASCULAR MORTALITY;
D O I
10.1038/ki.2014.128
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The incidence and prevalence of diabetes mellitus (DM) continue to grow markedly throughout the world, due primarily to the increase in type 2 DM (T2DM). Although improvements in DM and hypertension management have reduced the proportion of diabetic individuals who develop chronic kidney disease (CKD) and progress to end-stage renal disease (ESRD), the sheer increase in people developing DM will have a major impact on dialysis and transplant needs. This KDIGO conference addressed a number of controversial areas in the management of DM patients with CKD, including aspects of screening for CKD with measurements of albuminuria and estimated glomerular filtration rate (eGFR); defining treatment outcomes; glycemic management in both those developing CKD and those with ESRD; hypertension goals and management, including blockers of the renin-angiotensin-aldosterone system; and lipid management.
引用
收藏
页码:20 / 30
页数:11
相关论文
共 110 条
[11]   The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial [J].
Baigent, Colin ;
Landray, Martin J. ;
Reith, Christina ;
Emberson, Jonathan ;
Wheeler, David C. ;
Tomson, Charles ;
Wanner, Christoph ;
Krane, Vera ;
Cass, Alan ;
Craig, Jonathan ;
Neal, Bruce ;
Jiang, Lixin ;
Hooi, Lai Seong ;
Levin, Adeera ;
Agodoa, Lawrence ;
Gaziano, Mike ;
Kasiske, Bertram ;
Walker, Robert ;
Massy, Ziad A. ;
Feldt-Rasmussen, Bo ;
Krairittichai, Udom ;
Ophascharoensuk, Vuddidhej ;
Fellstrom, Bengt ;
Holdaas, Hallvard ;
Tesar, Vladimir ;
Wiecek, Andrzej ;
Grobbee, Diederick ;
de Zeeuw, Dick ;
Gronhagen-Riska, Carola ;
Dasgupta, Tanaji ;
Lewis, David ;
Herrington, William ;
Mafham, Marion ;
Majoni, William ;
Wallendszus, Karl ;
Grimm, Richard ;
Pedersen, Terje ;
Tobert, Jonathan ;
Armitage, Jane ;
Baxter, Alex ;
Bray, Christopher ;
Chen, Yiping ;
Chen, Zhengming ;
Hill, Michael ;
Knott, Carol ;
Parish, Sarah ;
Simpson, David ;
Sleight, Peter ;
Young, Alan ;
Collins, Rory .
LANCET, 2011, 377 (9784) :2181-2192
[12]   Preserving renal function in adults with hypertension and diabetes: A consensus approach [J].
Bakris, GL ;
Williams, M ;
Dworkin, L ;
Elliott, WJ ;
Epstein, M ;
Toto, R ;
Tuttle, K ;
Douglas, J ;
Hsueh, W ;
Sowers, J .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2000, 36 (03) :646-661
[13]   Effect of Candesartan on Microalbuminuria and Albumin Excretion Rate in Diabetes Three Randomized Trials [J].
Bilous, Rudy ;
Chaturvedi, Nish ;
Sjolie, Anne Katrin ;
Fuller, John ;
Klein, Ronald ;
Orchard, Trevor ;
Porta, Massimo ;
Parving, Hans-Henrik .
ANNALS OF INTERNAL MEDICINE, 2009, 151 (01) :11-U27
[14]   Screening for proteinuria in US adults - A cost-effectiveness analysis [J].
Boulware, LE ;
Jaar, BG ;
Tarver-Carr, ME ;
Brancati, FL ;
Powe, NR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (23) :3101-3114
[15]   Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J].
Brenner, BM ;
Cooper, ME ;
de Zeeuw, D ;
Keane, WF ;
Mitch, WE ;
Parving, HH ;
Remuzzi, G ;
Snapinn, SM ;
Zhang, ZX ;
Shahinfar, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) :861-869
[16]   Predictors of the progression of renal insufficiency in patients with insulin-dependent diabetes and overt diabetic nephropathy [J].
Breyer, JA ;
Bain, RP ;
Evans, JK ;
Nahman, NS ;
Lewis, EJ ;
Cooper, M ;
McGill, J ;
Berl, T ;
Rohde, R ;
Hunsicker, LG ;
Lachin, J ;
Greenhouse, SW ;
Verme, DA ;
Turlington, TR ;
Burrows, PK ;
Wish, J ;
Sheehan, J ;
Pohl, M ;
Berl, T ;
Santiago, G ;
Hunsicker, L ;
Kern, EFO ;
Lemann, J ;
Blementhal, S ;
Bresnahan, BS ;
Hebert, L ;
Goldfarb, S ;
Kobrin, S ;
Rodby, R ;
Levey, A ;
McLaughlin, M ;
Williams, M ;
McGill, J ;
Whittler, F ;
Rutecki, G ;
Cattran, D ;
Lietz, S ;
Valaitis, D ;
Hano, J ;
Maxwell, D ;
Porush, J ;
Spitalewitz, S ;
Shapiro, K ;
Adler, S ;
Tolchin, N ;
Hoy, W ;
Bernstein, R ;
Svetkey, L ;
Sharon, Z ;
Rausenbaum, B .
KIDNEY INTERNATIONAL, 1996, 50 (05) :1651-1658
[17]   Effect of inhibitors of the renin-angiotensin system and other anti hypertensive drugs on renal outcomes: systematic review and meta-analysis [J].
Casas, JP ;
Chua, WL ;
Loukogeorgakis, S ;
Vallance, P ;
Smeeth, L ;
Hingorani, AD ;
MacAllister, RJ .
LANCET, 2005, 366 (9502) :2026-2033
[18]   Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS) [J].
Colhoun, Helen M. ;
Betteridge, D. John ;
Durrington, Paul N. ;
Hitman, Graham A. ;
Neil, H. Andrew W. ;
Livingstone, Shona J. ;
Charlton-Menys, Valentine ;
DeMicco, David A. ;
Fuller, John H. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2009, 54 (05) :810-819
[19]   Tight Blood Pressure Control and Cardiovascular Outcomes Among Hypertensive Patients With Diabetes and Coronary Artery Disease [J].
Cooper-DeHoff, Rhonda M. ;
Gong, Yan ;
Handberg, Eileen M. ;
Bavry, Anthony A. ;
Denardo, Scott J. ;
Bakris, George L. ;
Pepine, Carl J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (01) :61-68
[20]   Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes [J].
de Boer, Ian H. ;
Sun, Wanjie ;
Cleary, Patricia A. ;
Lachin, John M. ;
Molitch, Mark E. ;
Steffes, Michael W. ;
Zinman, Bernard .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (25) :2366-2376