Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells

被引：61

作者：

Zhu, Mingming ^{[1
,3
]}

Zheng, Zongmei ^{[1
]}

Huang, Jiaming ^{[1
]}

Ma, Xiao ^{[3
]}

Huang, Cong ^{[3
]}

Wu, Rui ^{[3
]}

Li, Xiaoting ^{[2
,3
]}

Liang, Zhaofeng ^{[3
]}

Deng, Feifei ^{[3
]}

Wu, Jieshu ^{[2
,3
]}

Geng, Shanshan ^{[2
,3
]}

Xie, Chunfeng ^{[2
,3
]}

Zhong, Caiyun ^{[2
,3
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Clin Med 2, Dept Nutr, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Safety, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 09期

基金：

中国国家自然科学基金;

关键词：

cell proliferation; curcumin; miR-34a; prostate cancer; beta-catenin/c-myc; PROLIFERATION; METHYLATION; SUPPRESSION; EXPRESSION;

D O I：

10.1002/jcb.28828

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin is a phytochemical which exhibits significant inhibitory effect in multiple cancers including prostate cancer. MicroRNA-34a (miR-34a) was found to be a master tumor suppressor miRNA and regulated the growth of cancer cells. To date, however, the role of miR-34a in the anticancer action of curcumin against prostate cancer has been rarely reported. In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells. Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines. Inhibition of miR-34a activated beta-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells. Findings from this study revealed that miR-34a plays an important role in the antiproliferation effect of curcumin in prostate cancer.

引用

页码：15616 / 15624

页数：9

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