Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells

被引：59
|
作者：
Zhu, Mingming [1 ,3 ]
Zheng, Zongmei [1 ]
Huang, Jiaming [1 ]
Ma, Xiao [3 ]
Huang, Cong [3 ]
Wu, Rui [3 ]
Li, Xiaoting [2 ,3 ]
Liang, Zhaofeng [3 ]
Deng, Feifei [3 ]
Wu, Jieshu [2 ,3 ]
Geng, Shanshan [2 ,3 ]
Xie, Chunfeng [2 ,3 ]
Zhong, Caiyun [2 ,3 ]
机构：
[1] Nanjing Univ Chinese Med, Sch Clin Med 2, Dept Nutr, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Safety, Nanjing, Jiangsu, Peoples R China
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 09期
基金：
中国国家自然科学基金;
关键词：
cell proliferation; curcumin; miR-34a; prostate cancer; beta-catenin/c-myc; PROLIFERATION; METHYLATION; SUPPRESSION; EXPRESSION;
D O I：
10.1002/jcb.28828
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Curcumin is a phytochemical which exhibits significant inhibitory effect in multiple cancers including prostate cancer. MicroRNA-34a (miR-34a) was found to be a master tumor suppressor miRNA and regulated the growth of cancer cells. To date, however, the role of miR-34a in the anticancer action of curcumin against prostate cancer has been rarely reported. In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells. Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines. Inhibition of miR-34a activated beta-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells. Findings from this study revealed that miR-34a plays an important role in the antiproliferation effect of curcumin in prostate cancer.
引用
收藏
页码：15616 / 15624
页数：9
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