Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells

被引：61

作者：

Zhu, Mingming ^{[1
,3
]}

Zheng, Zongmei ^{[1
]}

Huang, Jiaming ^{[1
]}

Ma, Xiao ^{[3
]}

Huang, Cong ^{[3
]}

Wu, Rui ^{[3
]}

Li, Xiaoting ^{[2
,3
]}

Liang, Zhaofeng ^{[3
]}

Deng, Feifei ^{[3
]}

Wu, Jieshu ^{[2
,3
]}

Geng, Shanshan ^{[2
,3
]}

Xie, Chunfeng ^{[2
,3
]}

Zhong, Caiyun ^{[2
,3
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Clin Med 2, Dept Nutr, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Safety, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 09期

基金：

中国国家自然科学基金;

关键词：

cell proliferation; curcumin; miR-34a; prostate cancer; beta-catenin/c-myc; PROLIFERATION; METHYLATION; SUPPRESSION; EXPRESSION;

D O I：

10.1002/jcb.28828

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin is a phytochemical which exhibits significant inhibitory effect in multiple cancers including prostate cancer. MicroRNA-34a (miR-34a) was found to be a master tumor suppressor miRNA and regulated the growth of cancer cells. To date, however, the role of miR-34a in the anticancer action of curcumin against prostate cancer has been rarely reported. In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells. Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines. Inhibition of miR-34a activated beta-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells. Findings from this study revealed that miR-34a plays an important role in the antiproliferation effect of curcumin in prostate cancer.

引用

页码：15616 / 15624

页数：9

共 24 条

[1]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[2] The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention [J].

Alao, John P. .

MOLECULAR CANCER, 2007, 6 (1)

[3]

Bader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120

[4] Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics [J].

Chen, Bing-Jia ;

Wu, Yan-Ling ;

Tanaka, Yoshimasa ;

Zhang, Wen .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2014, 10 (10) :1084-1096

[5] Curcumin-Based Anti-Prostate Cancer Agents [J].

Chen, Qiao-Hong .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 15 (02) :138-156

[6] p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC [J].

Christoffersen, N. R. ;

Shalgi, R. ;

Frankel, L. B. ;

Leucci, E. ;

Lees, M. ;

Klausen, M. ;

Pilpel, Y. ;

Nielsen, F. C. ;

Oren, M. ;

Lund, A. H. .

CELL DEATH AND DIFFERENTIATION, 2010, 17 (02) :236-245

[7] miR-34a is an Intracellular and Exosomal Predictive Biomarker for Response to Docetaxel with Clinical Relevance to Prostate Cancer Progression [J].

Corcoran, Claire ;

Rani, Sweta ;

O'Driscoll, Lorraine .

PROSTATE, 2014, 74 (13) :1320-1334

[8] p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy [J].

El-Deiry, Wafik S. .

CANCER RESEARCH, 2016, 76 (18) :5189-5191

[9]

LANG JC, 1988, BRIT J CANCER, V58, P62

[10] MicroRNA-34a: a potential therapeutic target in human cancer [J].

Li, X. J. ;

Ren, Z. J. ;

Tang, J. H. .

CELL DEATH & DISEASE, 2014, 5 :e1327-e1327

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