Genotoxicity (mitotic recombination) of the cancer chemotherapeutic agents cisplatin and cytosine arabinoside in Aspergillus nidulans

被引：22
作者：
Miyamoto, C. T. [1 ]
Sant'Anna, J. R. [1 ]
Franco, C. C. S. [1 ]
Castro-Prado, M. A. A. [1 ]
机构：
[1] Univ Estadual Maringa, Dept Biol Celular & Genet, BR-87020900 Maringa, Parana, Brazil
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2007年 / 45卷 / 06期
关键词：
antineoplastic agents; tumor promoters; somatic recombination; second malignances;
D O I：
10.1016/j.fct.2006.12.018
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Cisplatin (cis-diamminedichloroplatinum, cis-DDP) and cytosine arabinoside (ara-C) are anticancer drugs used in the treatment of human cancer. The two chemotherapeutic drugs were tested in current research for their recombinogenic potential in diploid cells of Aspergillus nidulans. Non-cytotoxic concentrations of ara-C (0.4 and 0.8 mu M) and cis-DDP (1.5, 3.0 and 6.0 mu M) were strong recombinagens in A. nidulans UT448//A757 diploid strain, which induced homozygosis of recessive genetic markers, previously present in heterozygous condition. Drugs significantly increased homozygosity index (HI) values for five nutritional genetic markers when compared with those determined in the absence of anticancer drugs. Since mitotic recombination is a mechanism leading to malignant growth through loss of heterozygosity at tumor-suppressor loci, ara-C and cis-DDP may be characterized as secondary promoters of malignant neoplasia in diagnosed cancer patients, after chemotherapy treatment. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：1091 / 1095
页数：5
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