HER2 testing in gastric cancer: An update

被引：215

作者：

Abrahao-Machado, Lucas Faria ^{[1
]}

Scapulatempo-Neto, Cristovam ^{[1
]}

机构：

[1] Barretos Canc Hosp, Dept Pathol, Rua Antenor Duarte Villela 1331, BR-14784400 Barretos, SP, Brazil

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 19期

关键词：

Human epidermal growth factor receptor 2 testing; Gastric cancer; Immunohistochemistry; Scoring system; Trastuzumab; IN-SITU HYBRIDIZATION; GENE AMPLIFICATION; HELICOBACTER-PYLORI; SCORING SYSTEM; EXPRESSION; FISH; VALIDATION; PROGNOSIS; CARCINOMA; OVEREXPRESSION;

D O I：

10.3748/wjg.v22.i19.4619

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Human epidermal growth factor receptor 2 (HER2) overexpression is increasingly recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer. With the recent introduction of HER2 molecular targeted therapy for patients with advanced gastric cancer, determination of HER2 status is crucial in order to select patients who may benefit from this treatment. This paper provides an update on our knowledge of HER2 in gastric and gastroesophageal cancer, including the prognostic relevance of HER2, the key differences between HER2 protein expression interpretation in breast and gastric cancer, the detection methods and the immunohistochemistry scoring system.

引用

页码：4619 / 4625

页数：7

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