Dose recalculation in megavoltage cone-beam CT for treatment evaluation: Removal of cupping and truncation artefacts in scans of the thorax and abdomen

Purpose: To correct megavoltage cone-beam CT (MVCBCT) images of the thorax and abdomen for cupping and truncation artefacts to reconstruct the 3D-delivered dose distribution for treatment evaluation. Materials and methods: MVCBCT scans of three phantoms, three lung and two rectal cancer patients were acquired. The cone-beam projection images were iteratively corrected for cupping and truncation artefacts and the resulting primary transmission was used for cone-beam reconstruction. The reconstructed scans were merged into the planning CT scan (MVCBCT+). Dose distributions of clinical IMRT, stereotactic and conformal treatment plans were recalculated on the uncorrected and corrected MVCBCT+ scans using the treatment planning system and compared to the planned dose distribution. Results: The dose distributions on the corrected MVCBCT+ of the phantoms were accurate for 99% of the voxels within 2% or 2 mm. Using this method the errors in mean GTV dose reduced from about 10% to 1% for the patients. Conclusions: The method corrects cupping and truncation artefacts in cone-beam scans of the thorax and abdomen in addition to head-and-neck (demonstrated previously). The corrected scans can be used to calculate the influence of anatomical changes on the 3D-delivered dose distribution. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 94 (2010) 359-366