Adult Glioblastoma

被引：639

作者：

Alexander, Brian M. ^{[1
]}

Cloughesy, Timothy F. ^{[2
]}

机构：

[1] Harvard Med Sch, Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷 / 21期

关键词：

NEWLY-DIAGNOSED GLIOBLASTOMA; PROGRESSION-FREE SURVIVAL; CENTRAL-NERVOUS-SYSTEM; RANDOMIZED PHASE-III; RADIATION-THERAPY; POSTOPERATIVE TREATMENT; PLUS TEMOZOLOMIDE; MALIGNANT GLIOMA; CLINICAL-TRIALS; END-POINT;

D O I：

10.1200/JCO.2017.73.0119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is a rare tumor and one of the most challenging malignancies to treat in all of oncology. Although advances have been made in the treatment of GBM, encouraging outcomes typically are not observed; patients diagnosed with these tumors generally have a dismal prognosis and poor quality of life as the disease progresses. This review summarizes the clinical presentation of GBM, diagnostic methods, evidentiary basis for the current standards of care, and investigational approaches to treat or manage GBM. Because the track record for developing effective therapies for GBM has been dismal, we also review the challenges to successful therapeutic and biomarker development. (C) 2017 by American Society of Clinical Oncology

引用

页码：2402 / +

页数：9

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