Adult Glioblastoma

被引：603

作者：

Alexander, Brian M. ^{[1
]}

Cloughesy, Timothy F. ^{[2
]}

机构：

[1] Harvard Med Sch, Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷 / 21期

关键词：

NEWLY-DIAGNOSED GLIOBLASTOMA; PROGRESSION-FREE SURVIVAL; CENTRAL-NERVOUS-SYSTEM; RANDOMIZED PHASE-III; RADIATION-THERAPY; POSTOPERATIVE TREATMENT; PLUS TEMOZOLOMIDE; MALIGNANT GLIOMA; CLINICAL-TRIALS; END-POINT;

D O I：

10.1200/JCO.2017.73.0119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is a rare tumor and one of the most challenging malignancies to treat in all of oncology. Although advances have been made in the treatment of GBM, encouraging outcomes typically are not observed; patients diagnosed with these tumors generally have a dismal prognosis and poor quality of life as the disease progresses. This review summarizes the clinical presentation of GBM, diagnostic methods, evidentiary basis for the current standards of care, and investigational approaches to treat or manage GBM. Because the track record for developing effective therapies for GBM has been dismal, we also review the challenges to successful therapeutic and biomarker development. (C) 2017 by American Society of Clinical Oncology

引用

页码：2402 / +

页数：9

共 88 条

[1] Brain Malignancy Steering Committee clinical trials planning workshop: Report from the Targeted Therapies Working Group
Alexander, Brian M.
Galanis, Evanthia
Yung, W. K. Alfred
Ballman, Karla V.
Boyett, James M.
Cloughesy, Timothy F.
Degroot, John F.
Huse, Jason T.
Mann, Bhupinder
Mason, Warren
Mellinghoff, Ingo K.
Mikkelsen, Tom
Mischel, Paul S.
O'Neill, Brian P.
Prados, Michael D.
Sarkaria, Jann N.
Tawab-Amiri, Abdul
Trippa, Lorenzo
Ye, Xiaobu
Ligon, Keith L.
Berry, Donald A.
Wen, Patrick Y.
[J]. NEURO-ONCOLOGY, 2015, 17 (02) : 180 - 188
[2] Biomarker-based adaptive trials for patients With glioblastoma-lessons from I-SPY 2
Alexander, Brian M.
Wen, Patrick Y.
Trippa, Lorenzo
Reardon, David A.
Yung, Wai-Kwan Alfred
Parmigiani, Giovanni
Berry, Donald A.
[J]. NEURO-ONCOLOGY, 2013, 15 (08) : 972 - 978
[3] Signatures of mutational processes in human cancer
Alexandrov, Ludmil B.
Nik-Zainal, Serena
Wedge, David C.
Aparicio, Samuel A. J. R.
Behjati, Sam
Biankin, Andrew V.
Bignell, Graham R.
Bolli, Niccolo
Borg, Ake
Borresen-Dale, Anne-Lise
Boyault, Sandrine
Burkhardt, Birgit
Butler, Adam P.
Caldas, Carlos
Davies, Helen R.
Desmedt, Christine
Eils, Roland
Eyfjord, Jorunn Erla
Foekens, John A.
Greaves, Mel
Hosoda, Fumie
Hutter, Barbara
Ilicic, Tomislav
Imbeaud, Sandrine
Imielinsk, Marcin
Jaeger, Natalie
Jones, David T. W.
Jones, David
Knappskog, Stian
Kool, Marcel
Lakhani, Sunil R.
Lopez-Otin, Carlos
Martin, Sancha
Munshi, Nikhil C.
Nakamura, Hiromi
Northcott, Paul A.
Pajic, Marina
Papaemmanuil, Elli
Paradiso, Angelo
Pearson, John V.
Puente, Xose S.
Raine, Keiran
Ramakrishna, Manasa
Richardson, Andrea L.
Richter, Julia
Rosenstiel, Philip
Schlesner, Matthias
Schumacher, Ton N.
Span, Paul N.
Teague, Jon W.
[J]. NATURE, 2013, 500 (7463) : 415 - +
[4] Hospitalization burden and survival among older glioblastoma patients
Arvold, Nils D.
Wang, Yun
Zigler, Cory
Schrag, Deborah
Dominici, Francesca
[J]. NEURO-ONCOLOGY, 2014, 16 (11) : 1530 - 1540
[5] Changes in Brain Glioma Incidence and Laterality Correlates with Use of Mobile Phones - a Nationwide Population Based Study in Israel
Barchana, Micha
Margaliot, Menahem
Liphshitz, Irena
[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (11) : 5857 - 5863
[6] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
Batchelor, Tracy T.
Sorensen, A. Gregory
di Tomaso, Emmanuelle
Zhang, Wei-Ting
Duda, Dan G.
Cohen, Kenneth S.
Kozak, Kevin R.
Cahill, Daniel P.
Chen, Poe-Jou
Zhu, Mingwang
Ancukiewicz, Marek
Mrugala, Maciej M.
Plotkin, Scott
Drappatz, Jan
Louis, David N.
Ivy, Percy
Scadden, David T.
Benner, Thomas
Loeffler, Jay S.
Wen, Patrick Y.
Jain, Rakesh K.
[J]. CANCER CELL, 2007, 11 (01) : 83 - 95
[7] Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma
Batchelor, Tracy T.
Mulholland, Paul
Neyns, Bart
Nabors, L. Burt
Campone, Mario
Wick, Antje
Mason, Warren
Mikkelsen, Tom
Phuphanich, Surasak
Ashby, Lynn S.
DeGroot, John
Gattamaneni, Rao
Cher, Lawrence
Rosenthal, Mark
Payer, Franz
Juergensmeier, Juliane M.
Jain, Rakesh K.
Sorensen, A. Gregory
Xu, John
Liu, Qi
van den Bent, Martin
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (26) : 3212 - 3218
[8] Adaptive clinical trials in oncology
Berry, Donald A.
[J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2012, 9 (04) : 199 - 207
[9] The Platform Trial An Efficient Strategy for Evaluating Multiple Treatments
Berry, Scott M.
Connor, Jason T.
Lewis, Roger J.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (16): : 1619 - 1620
[10] A MEDICAL-RESEARCH-COUNCIL TRIAL OF 2 RADIOTHERAPY DOSES IN THE TREATMENT OF GRADE-3 AND GRADE-4 ASTROCYTOMA
BLEEHEN, NM
STENNING, SP
[J]. BRITISH JOURNAL OF CANCER, 1991, 64 (04) : 769 - 774

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