Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering

被引:17
作者
Koo, Min-Ah [1 ,2 ]
Lee, Mi Hee [1 ]
Park, Jong-Chul [1 ,2 ]
机构
[1] Yonsei Univ, Dept Med Engn, Coll Med, Seoul 03722, South Korea
[2] Yonsei Univ, Coll Med, Brain Korea 21 PLUS Project Med Sci, Seoul 03722, South Korea
基金
新加坡国家研究基金会;
关键词
cell sheet; cell detachment; reactive oxygen species; MULTILAYERED KERATINOCYTE SHEETS; REACTIVE OXYGEN; MAGNETITE NANOPARTICLES; PHOTODYNAMIC THERAPY; CULTURE DISHES; DETACHMENT; TEMPERATURE; MECHANISMS; SURFACES; HARVEST;
D O I
10.3390/ijms20225656
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell sheet engineering has evolved rapidly in recent years as a new approach for cell-based therapy. Cell sheet harvest technology is important for producing viable, transplantable cell sheets and applying them to tissue engineering. To date, most cell sheet studies use thermo-responsive systems to detach cell sheets. However, other approaches have been reported. This review provides the progress in cell sheet detachment techniques, particularly reactive oxygen species (ROS)-responsive strategies. Therefore, we present a comprehensive introduction to ROS, their application in regenerative medicine, and considerations on how to use ROS in cell detachment. The review also discusses current limitations and challenges for clarifying the mechanism of the ROS-responsive cell sheet detachment.
引用
收藏
页数:12
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