Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity

被引：37

作者：

Ahn, Jongmin ^{[1
,2
]}

Chae, Hee-Sung ^{[3
,4
]}

Chin, Young-Won ^{[3
,4
]}

Kim, Jinwoong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea

[3] Dongguk Univ Seoul, Coll Pharm, Gyeonggi Do 10326, South Korea

[4] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, Gyeonggi Do 10326, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 12期

关键词：

Alkaloids; Benzamides; beta-Carboline alkaloid; Houttuynia cordata; Anti-inflammatory; APORPHINE ALKALOIDS; TRADITIONAL MEDICINE; DERIVATIVES; LEAVES; CONSTITUENTS; CHEMISTRY; FRUITS; VIRUS; CELLS; PODS;

D O I：

10.1016/j.bmcl.2017.04.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7 mu M. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2807 / 2811

页数：5

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