Pleiotropic effects of oxidized phospholipids

被引：92

作者：

Bochkov, Valery ^{[1
]}

Gesslbauer, Bernd ^{[1
]}

Mauerhofer, Christina ^{[1
]}

Philippova, Maria ^{[2
]}

Erne, Paul ^{[2
]}

Oskolkova, Olga V. ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Dept Pharmaceut Chem, Inst Pharmaceut Sci, Graz, Austria

[2] Basel Univ Hosp, Dept Biomed, Signaling Lab, Basel, Switzerland

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2017年 / 111卷

基金：

奥地利科学基金会;

关键词：

Oxidized phospholipids; Biological activities; Analytics of oxidized phospholipids; Receptors of oxidized phospholipids; PLATELET-ACTIVATING-FACTOR; LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; ULTRAVIOLET-B RADIATION; ENDOTHELIAL BARRIER ENHANCEMENT; MONOCYTE CHEMOTACTIC PROTEIN-1; RETINAL-PIGMENT EPITHELIUM; ELEMENT-BINDING PROTEIN; TOLL-LIKE RECEPTOR-4; MASS-SPECTROMETRY;

D O I：

10.1016/j.freeradbiomed.2016.12.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests that OxPLs are biomarkers of atherosclerosis and other pathologies. In addition, successful application of experimental drugs based on structural scaffold of OxPLs in animal models of inflammation was recently reported. This review briefly summarizes current knowledge on generation, methods of quantification and biological activities of OxPLs. Furthermore, receptor and cellular mechanisms of these effects are discussed. The goal of the review is to give a broad overview of this class of lipid mediators inducing pleiotropic biological effects.

引用

收藏

页码：6 / 24

页数：19

相关论文

共 229 条

[41] Platelet Activation by Low Concentrations of Intact Oxidized LDL Particles Involves the PAF Receptor [J].

Chen, Rui ;

Chen, Xi ;

Salomon, Robert G. ;

McIntyre, Thomas M. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (03) :363-371

[42] Oxidized Phospholipids Induce Type VIII Collagen Expression and Vascular Smooth Muscle Cell Migration [J].

Cherepanova, Olga A. ;

Pidkovka, Nataliya A. ;

Sarmento, Olga F. ;

Yoshida, Tadashi ;

Gan, Qiong ;

Adiguzel, Eser ;

Bendeck, Michelle P. ;

Berliner, Judith ;

Leitinger, Norbert ;

Owens, Gary K. .

CIRCULATION RESEARCH, 2009, 104 (05) :609-U112

[43] Hydrophilic interaction liquid chromatography-mass spectrometry of (lyso)phosphatidic acids, (lyso)phosphatidylserines and other lipid classes [J].

Cifkova, Eva ;

Hajek, Roman ;

Lisa, Miroslav ;

Holcapek, Michal .

JOURNAL OF CHROMATOGRAPHY A, 2016, 1439 :65-73

[44] Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection [J].

Clark, Stephen R. ;

Guy, Christopher J. ;

Scurr, Martin J. ;

Taylor, Philip R. ;

Kift-Morgan, Ann P. ;

Hammond, Victoria J. ;

Thomas, Christopher P. ;

Coles, Barbara ;

Roberts, Gareth W. ;

Eberl, Matthias ;

Jones, Simon A. ;

Topley, Nicholas ;

Kotecha, Sailesh ;

O'Donnell, Valerie B. .

BLOOD, 2011, 117 (06) :2033-2043

[45] Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway [J].

Cole, AL ;

Subbanagounder, G ;

Mukhopadhyay, S ;

Berliner, JA ;

Vora, DK .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (08) :1384-1390

[46] Critical Role of IL-17RA in Immunopathology of Influenza Infection [J].

Crowe, Christopher R. ;

Chen, Kong ;

Pociask, Derek A. ;

Alcorn, John F. ;

Krivich, Cameron ;

Enelow, Richard I. ;

Ross, Ted M. ;

Witztum, Joseph L. ;

Kolls, Jay K. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (08) :5301-5310

[47] Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy [J].

Cruz, Daniel ;

Watson, Andrew D. ;

Miller, Christopher S. ;

Montoya, Dennis ;

Ochoa, Maria-Teresa ;

Sieling, Peter A. ;

Gutierrez, Miguel A. ;

Navab, Mohamad ;

Reddy, Srinivasa T. ;

Witztum, Joseph L. ;

Fogelman, Alan M. ;

Rea, Thomas H. ;

Eisenberg, David ;

Berliner, Judith ;

Modlin, Robert L. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (08) :2917-2928

[48] Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids [J].

Davies, Sean S. ;

Guo, Lilu .

CHEMISTRY AND PHYSICS OF LIPIDS, 2014, 181 :1-33

[49] Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists [J].

Davies, SS ;

Pontsler, AV ;

Marathe, GK ;

Harrison, KA ;

Murphy, RC ;

Hinshaw, JC ;

Prestwich, GD ;

St Hilaire, A ;

Prescott, SM ;

Zimmerman, GA ;

McIntyre, TM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) :16015-16023

[50] Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner [J].

Delerive, P ;

Furman, C ;

Teissier, E ;

Fruchart, JC ;

Duriez, P ;

Staels, B .

FEBS LETTERS, 2000, 471 (01) :34-38

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