Pleiotropic effects of oxidized phospholipids

被引：92
作者：
Bochkov, Valery [1 ]
Gesslbauer, Bernd [1 ]
Mauerhofer, Christina [1 ]
Philippova, Maria [2 ]
Erne, Paul [2 ]
Oskolkova, Olga V. [1 ]
机构：
[1] Karl Franzens Univ Graz, Dept Pharmaceut Chem, Inst Pharmaceut Sci, Graz, Austria
[2] Basel Univ Hosp, Dept Biomed, Signaling Lab, Basel, Switzerland
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2017年 / 111卷
基金：
奥地利科学基金会;
关键词：
Oxidized phospholipids; Biological activities; Analytics of oxidized phospholipids; Receptors of oxidized phospholipids; PLATELET-ACTIVATING-FACTOR; LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; ULTRAVIOLET-B RADIATION; ENDOTHELIAL BARRIER ENHANCEMENT; MONOCYTE CHEMOTACTIC PROTEIN-1; RETINAL-PIGMENT EPITHELIUM; ELEMENT-BINDING PROTEIN; TOLL-LIKE RECEPTOR-4; MASS-SPECTROMETRY;
D O I：
10.1016/j.freeradbiomed.2016.12.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests that OxPLs are biomarkers of atherosclerosis and other pathologies. In addition, successful application of experimental drugs based on structural scaffold of OxPLs in animal models of inflammation was recently reported. This review briefly summarizes current knowledge on generation, methods of quantification and biological activities of OxPLs. Furthermore, receptor and cellular mechanisms of these effects are discussed. The goal of the review is to give a broad overview of this class of lipid mediators inducing pleiotropic biological effects.
引用
收藏
页码：6 / 24
页数：19
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